Mesothelioma Survival Rate

Survival rates are presented as percentages. For instance, the 5-year survival rate for pleural mesothelioma patients who receive treatment is 12%. This means 12 out of 100 people with pleural mesothelioma can expect to live for five years following diagnosis. For the most common forms of mesothelioma, between 73% and 92% of patients live longer than one year. Five-year survival ranges widely from 12% – 65%.

Survival rates may vary depending on a number of different factors. Mesothelioma type, treatment, age, gender and other factors can all affect survival rate.

Historically, a mesothelioma diagnosis was fatal for most people. But scientific advances are changing that. Survival rates have improved, particularly for malignant pleural mesothelioma and peritoneal mesothelioma. Survival rates may be climbing because of earlier detection and newer treatments.

How Are Mesothelioma Survival Rates Used?

Survival rates can provide useful information for doctors, patients and mesothelioma researchers. For example, they can be used to:

• Determine individual treatment options: Survival rates can help determine how a patient may respond to certain treatments. Doctors can look for high survival rates among patients with diagnoses similar to their patient’s. They can then consider the treatments these other patients received.
• Explore new treatment options: Researchers often compare survival rates between patients receiving established treatments and those receiving newer treatments. This comparison can help them determine if a new treatment might help improve survival.
• Understand prognosis: Doctors base prognosis on several factors, including mesothelioma type and stage of disease. They can consider survival rates for people with similar case profiles to help determine a patient’s outlook. This data can also help patients understand the likely progression of their case.

However, survival rates do not determine actual survival. They are useful statistics in certain situations. But they are based on a group of patients, not on an individual patient’s unique case. Individual patients may experience different outcomes. Even though mesothelioma often has a low long-term survival rate, it is possible for some patients. Individual mesothelioma survivor’s stories reflect this.

02. Factors Impacting Survival

Factors Affecting Mesothelioma Survival Rates

Many factors can affect mesothelioma survival rate statistics. For example, younger mesothelioma patients tend to have better survival rates. Women also tend to survive longer than men.

Factors that may influence mesothelioma survival rate include:

• Age
• Blood chemistry
• Gender
• Mesothelioma cell type
• Mesothelioma stage
• Mesothelioma tumor location
• Overall patient health
• Race

These factors are not independent of one another. They may influence each other, resulting in different survival rates. For example, an 89-year-old patient in great health may have better survival than a 28-year-old patient with several serious health conditions.

5-Year Mesothelioma Survival Rates by Age and Gender*
Age at Diagnosis	Male	Female
<45	32%	53%
45 – 54	18%	32%
55 – 64	13%	18%
65 – 74	7%	16%
75+	4%	7%

_{*Includes individuals who did and did not receive treatment}

Age

Patient age at the time of diagnosis may impact survival rates. According to data, younger patients have higher 5-year survival rates than older patients.

This higher survival rate may be the result of differences in the overall health of younger versus older patients. Older patients may have existing health conditions or poorer overall health. These factors may limit treatment options, potentially decreasing survival rates for older patients.

1-Year Mesothelioma Survival by Age
Under 50 years	66%
50 to 64 years	55%
65+ years	37%
75+ years	31%

Gender

Biological sex may also affect survival rates. Female mesothelioma patients tend to have better overall survival rates than male patients. Some theories that try to explain this difference include:

• Estrogen: Some researchers suggest that estrogen in the bloodstream may interact with tumor cells. This may contribute to higher survival rates among patients with estrogen receptors on their tumors.
• Type of mesothelioma common in women: Women are more likely to develop peritoneal mesothelioma than pleural mesothelioma. Peritoneal mesothelioma has a higher survival rate than pleural mesothelioma.

Gender is just one factor that may contribute to survival. A mesothelioma specialist can help patients understand how this and other factors may affect survival.

Mesothelioma Survival Rates by Gender
	1-Year Survival	3-Year Survival	5-Year Survival
Female	49%	24%	16%
Male	40%	13%	7%

Mesothelioma Cell Type

Mesothelioma cell type may affect survival rates because each cell type responds differently to treatment. There are three main types of mesothelioma cells: epithelial, sarcomatoid and biphasic.

Epithelioid mesothelioma generally has the highest survival rates of the cell types, as it responds best to treatment. Sarcomatoid mesothelioma has the least favorable survival rate. This may be because sarcomatoid cells are less responsive to treatment. Biphasic mesothelioma is a combination of epithelioid and sarcomatoid cell types. Survival rate for biphasic mesothelioma varies according to which cell type is dominant.

Pleural Mesothelioma 2-Year Survival Rate by Cell Type*
	2-Year Survival
Epithelioid	40%
Sarcomatoid	10%
Biphasic	19%

_{*All data in this table indicates survival rate with treatment}

Peritoneal Mesothelioma 5-Year Survival by Cell Type*
	5-Year Survival
Epithelioid	35%
Sarcomatoid & biphasic	75%

_{*All data in this table indicates survival rate with treatment}

Mesothelioma Stage

The stage of mesothelioma at the time of diagnosis may also influence survival rates. Early detection may be the best way to improve a patient’s mesothelioma prognosis.

Survival rates by stage may also vary depending on the staging system used. There are two main staging systems:

• SEER staging system: SEER stands for Surveillance, Epidemiology, and End Results. It is a nationwide program that tracks cancer statistics. The program divides cancer into three stages: localized, regional and distant. These terms describe how much of the cancer has remained localized or has spread to other parts of the body.
• TNM staging system: TNM stands for tumor, node and metastasis. Medical publications commonly use this system. It separates cancer into stages numbered one through four. Stages 1 and 2 mesothelioma are likely localized and can be targeted with aggressive treatment. Stage 3 and 4 mesothelioma have likely spread to other parts of the body and may be more difficult to treat.

The biggest difference between SEER staging and TNM staging is the number of stages included in the system. SEER has three stages. TNM has four stages. As such, TNM staging may provide more personalized information than SEER staging. Doctors may be able to more accurately predict prognosis from TNM staging than SEER staging.

Patients should discuss staging and prognosis questions with a mesothelioma doctor. The doctor can help patients understand how staging may affect their mesothelioma prognosis.

Pleural Mesothelioma Survival by TNM Stage*
	1-Year Survival	2-Year Survival	5-Year Survival
Stage 1	75%	41%	33%
Stage 2	70%	39%	9%
Stage 3	62%	29%	6%
Stage 4	52%	24%	4%

_{*All data in this table indicates survival rate with treatment}

Tumor Location

One of the most important indicators of patient survival rate is tumor location. Where mesothelioma originates in the body can determine viable treatment options. This, in turn, can affect how long a person with mesothelioma lives. The most common mesothelioma locations are the lining around the lungs (pleural mesothelioma) and the lining around the abdomen (peritoneal mesothelioma). Depending on tumor location, survival can range from months to years following diagnosis. In general, peritoneal mesothelioma has a more favorable survival rate.

Mesothelioma may occur in other places in rare cases, including the lining around the heart and lining around the testes. These rare types of mesothelioma have only a small amount of data behind their survival statistics. This can make drawing broad conclusions based on their survival rates difficult.

Pleural vs. Peritoneal Mesothelioma Survival Rates*
	1-Year Survival	5-Year Survival
Pleural mesothelioma	73%	12%
Peritoneal mesothelioma	92%	65%

_{*All data in this table indicates survival rate with treatment}

Other Factors Impacting Survival

In addition to tumor location, stage of disease and patient age and gender, a variety of other factors impact survival rates, including:

• Genetics: People with the biomarker BRCA1-associated protein-1 (BAP1) may live for longer with mesothelioma. Detection of this biomarker is associated with longer survival rates.
• Blood chemistry: High levels of platelets or white blood cells and low hemoglobin levels have been shown to negatively impact mesothelioma survival rates. According to research, elevated white blood cell counts lead to lower survival rates for patients with non-epithelial mesothelioma.
• Overall health: Poor health indicators may be associated with lower survival rates. This includes both biological and lifestyle factors that may negatively impact a person’s health. For example, patients with a history of smoking may have lower survival rates than non-smokers.
• Race: According to SEER data from 2009 – 2015, black patients had a 5-year survival rate of 17%. Comparatively, white patients had a 5-year survival rate of 10%. However, the reason for this difference is still largely unstudied. In general, mesothelioma is less well-documented among black people than white people. This makes it difficult to draw conclusions about survival rates and race.

Ultimately, patients should discuss their diagnosis with their physician to better understand survival expectations for their individual cases.

03. Survival Rate by Type

Mesothelioma Survival Rate by Type

Type of mesothelioma plays a large role in survival rates. A patient may be expected to survive longer depending on the type of mesothelioma they have. The most common types of mesothelioma are pleural and peritoneal. Therefore, survival rates for these types represent a larger group of patients than rates for rarer types.

Pleural Mesothelioma Survival Rate

Pleural mesothelioma occurs in the lining around the lungs, also known as the pleura. It is the most common type of mesothelioma, accounting for 80% – 90% of mesothelioma diagnoses.

Pleural Mesothelioma Survival Rates With Treatment
1-year survival rate	73%
3-year survival rate	23%
5-year survival rate	12%
10-year survival rate	5%

Patients with pleural mesothelioma who receive treatment tend to live longer than those who do not receive treatment. Pleural mesothelioma is commonly treated using a multimodal approach. This approach may combine treatments such as chemotherapy, immunotherapy, radiation and surgery.

In studies, two surgeries have extended pleural mesothelioma life expectancy in combination with other treatments. Common pleural mesothelioma surgeries include:

• Extrapleural pneumonectomy (EPP)
• Pleurectomy/decortication (P/D)

Combining these surgeries with other treatments may help further improve life expectancy.

Peritoneal Mesothelioma Survival Rate

Peritoneal mesothelioma occurs in the tissue lining the abdomen, also known as the peritoneum. This type of mesothelioma has some of the best survival rates among people with this rare cancer.

Peritoneal Mesothelioma Survival Rates With Treatment
1-year survival rate	92%
3-year survival rate	74%
5-year survival rate	65%
10-year survival rate	39%

Patients tend to live longer if they receive treatment for their peritoneal mesothelioma. A combination of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is standard. HIPEC is a heated chemotherapy wash applied to the abdominal cavity.

Peritoneal mesothelioma may also be treated with immunotherapy, radiation or emerging treatment options.

Rare Forms of Mesothelioma Survival Rate

Pleural and peritoneal mesothelioma are the most common mesothelioma types. Other types include pericardial and testicular mesothelioma. Pericardial mesothelioma develops in the lining around the heart and accounts for less than 1% of all diagnoses. Testicular mesothelioma develops in the membrane lining the testes. It accounts for less than 1% of all diagnoses.

Data is currently thin but appears to show that testicular mesothelioma has a favorable survival rate. This is due to the location of the cancer and treatment options. Data about pericardial mesothelioma shows a high rate of mortality. But the rareness of these diseases means the survival rates reflect only a small group of patients. This makes it difficult to draw broad conclusions about how long a person with these types of mesothelioma may live.

Survival Rates of Rare Types of Mesothelioma
	Pericardial*	Testicular**
1-year survival rate	26%	Not reported
3-year survival rate	14%	Not reported
5-year survival rate	9%	58%
10-year survival rate	Not reported	45%

_{*Pericardial data indicates survival rate with treatment
**Testicular data counts disease-specific survival, meaning patient deaths are only counted if they died of testicular mesothelioma}

04. Improving Survival

Improving Mesothelioma Cancer Survival

Mesothelioma treatment may be the most influential factor in a patient’s survival. Studies show multimodal therapy can improve survival better than individual treatments. The type of treatment a patient may receive depends on their individual diagnosis. A multimodal approach may include chemotherapy, radiation, surgery or immunotherapy. Patients may also be eligible for experimental treatments through clinical trials.

Treatment options are largely dependent on the type and stage of mesothelioma. Doctors may be able to treat stage 1 or stage 2 mesothelioma with aggressive surgery. Surgical removal of tumors and cancerous tissues combined with other forms of treatment can improve survival.

Those with a later stage diagnosis may not have the same surgical options. By stages 3 and 4, the cancer has typically spread to the lymph nodes or distant organs and is difficult to remove. Patients ineligible for surgery may receive chemotherapy, radiation and/or immunotherapy.

Mesothelioma doctors can tailor treatment plans to a patient’s individual diagnosis. These individualized plans can help give a patient the best chance of improved survival.

Pleural Mesothelioma Survival Rates by Treatment Type*
Treatment Type	1-Year Survival	2-Year Survival	3-Year Survival
Multimodal treatment: Chemotherapy, surgery and repeat chemotherapy for certain patients	93%	Not reported	65%
Multimodal treatment: Chemotherapy, surgery, then radiation	Not reported	50%	Not reported
Chemotherapy alone	58%	27%	15%
Immunotherapy: Opdivo® +Yervoy®	68%	41%	23%

_{*Information in this table is aggregated from a number of studies. “Not reported” indicates areas where certain survival rates were not reported in certain studies.}

Peritoneal Mesothelioma Survival Rates by Treatment Type*
Treatment Type	1-Year Survival	3-Year Survival	5-Year Survival
Multimodal treatment: Surgery and HIPEC	83%	62%	52%
Multimodal treatment: Surgery, HIPEC, EPIC and NIPEC	Not reported	Not reported	75%

_{*Information in this table is aggregated from a number of studies. “Not reported” indicates areas where certain survival rates were not reported in certain studies.}

Other Factors Impacting Survival Rates

Treatment is generally the best way to improve survival for mesothelioma patients. Patients also have other options available that may impact survival and improve quality of life. Diet, nutrition and alternative medicines may all provide certain benefits for mesothelioma patients. These other options are all seen as supplements, not replacements, for more standard therapy. There is little evidence that they may improve survival rates.

Diet and nutrition are important before, during and after mesothelioma treatment. A good diet may help maintain overall health and quality of life. Patients who are in better health are more likely to be eligible for surgery, which may help improve survival. Dietitians can recommend the best foods for mesothelioma patients.

Alternative treatments are also available to patients. These may include dietary supplements, exercise and/or meditation, among other things. They may help manage symptoms and offer comfort to patients.

05. Mesothelioma Survivors

Mesothelioma Survivor Stories

Mesothelioma survival rates provide a general outlook on survival but don’t define individual cases. Recent years have seen improvements in diagnostic tools and treatment techniques. These milestones have led to more long-term mesothelioma survivors. Mesothelioma survivors offer hope to patients and their loved ones following diagnosis.

A mesothelioma diagnosis can feel isolating. Patients may find comfort in reaching out to the supportive survivor community. Having a support system may help improve their quality of life before, during and after treatment.

06. Common Questions