Clinical Trials Recruiting Mesothelioma Patients

Author: Francis Perry Wilson, MD

Reviewer: Amy Zappone

Last Updated: 10/19/2026

The clinical trials below are recruiting mesothelioma patients now. Each study has its own eligibility requirements, and doctors can help patients find one that may be appropriate. Depending on the study, participants may receive an experimental or standard treatment or take part in research that does not test a treatment.

Learn About Mesothelioma Clinical Trials in Our Free Guide

Who Should Consider a Mesothelioma Clinical Trial?

Patients with any type of mesothelioma can ask their oncologists whether a clinical trial may be appropriate for them.

For pleural mesothelioma, the 2025 guideline from the American Society of Clinical Oncology (ASCO) recommends that certain treatments be performed at experienced centers, preferably or exclusively within clinical trials, depending on the procedure. These include:

Surgery to remove as much of the tumor as possible, for select patients who qualify
Radiation to one whole side of the chest before or after certain types of surgery
Chemotherapy or photodynamic therapy delivered directly into the chest cavity

For peritoneal mesothelioma, a 2025 national expert consensus guideline also supports considering clinical trial enrollment.

Clinical trial participation may involve risks. Patients should discuss the potential benefits and risks of enrolling in a clinical trial with their oncologists.

More information on clinical trial safety, process, costs and enrollment is available on our Clinical Trials Overview page.

Current Mesothelioma Trial Listings

The trials below are recruiting mesothelioma patients, based on ClinicalTrials.gov records. Each title links to the study’s official record, which lists who can join, where the study takes place and who to contact.

Recruiting status can change, and the official record is the most up-to-date source. Some studies test new treatments, while others collect tissue samples or test imaging and screening methods. Patients should review any study with their oncologist before contacting the research team.

SW-682 in Advanced Solid Tumors

Conditions: Mesothelioma
Last Updated: 10/30/2026
Status: Recruiting

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Conditions: Mesothelioma
Last Updated: 10/29/2026
Status: Recruiting

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Conditions: Mesothelioma
Last Updated: 10/29/2026
Status: Recruiting

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Conditions: Mesothelioma
Last Updated: 10/29/2026
Status: Recruiting

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Conditions: Mesothelioma
Last Updated: 10/28/2026
Status: Recruiting

Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma

Conditions: Mesothelioma
Last Updated: 10/26/2026
Status: Recruiting

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

Conditions: Mesothelioma
Last Updated: 10/26/2026
Status: Recruiting

A 2-part Phase 1/2 Open-label Trial on ODM-212

Conditions: Mesothelioma
Last Updated: 10/22/2026
Status: Recruiting

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

Conditions: Mesothelioma
Last Updated: 10/22/2026
Status: Recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma