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HomeTreatmentClinical TrialsClinical Trials – Recruiting

Participating in a clinical trial allows those who have been diagnosed with a serious illness, like mesothelioma, to contribute to medical research. Each clinical trial has unique criteria and guidelines that prospective participants must meet in order to be considered for inclusion in the study. Because there are both benefits and risks to participating in a clinical trial it is always best to discuss any interest you may have with your doctor. Provided below is a list of active mesothelioma clinical trials that are still recruiting and enrolling participants. Click on a link to learn more about each study and the criteria for participation.

Mithramycin for Lung, Esophagus, and Other Chest Cancers


Conditions: Esophageal Neoplasms, Mesothelioma, Gastrointestinal Neoplasms, Digestive System Neoplasms

Last Updated: July 23, 2019

Status: Recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors


Conditions: Carcinoma, Neoplasms, Carcinoma, Squamous Cell, Adenocarcinoma, Neoplasms, Germ Cell and Embryonal, Mesothelioma, Breast Neoplasms, Nasopharyngeal Carcinoma, Cholangiocarcinoma, Carcinoma, Basal Cell, Gastrointestinal Stromal Tumors, Germinoma, Ovarian Neoplasms, Carcinoma, Transitional Cell, Carcinoma, Adenoid Cystic, Teratoma, Carcinoid Tumor, Adenocarcinoma of Lung, Carcinoma, Neuroendocrine, Seminoma, Pheochromocytoma, Choriocarcinoma, Cystadenocarcinoma, Neoplasms, Second Primary, Carcinoma, Endometrioid, Cystadenocarcinoma, Serous, Chordoma, Paraganglioma, Carotid Body Tumor, Hemangiosarcoma, Trophoblastic Neoplasms, Gestational Trophoblastic Disease, Adenocarcinoma, Mucinous, Adenocarcinoma, Clear Cell, Nerve Sheath Neoplasms, Neurofibrosarcoma, Testicular Neoplasms, Cystadenocarcinoma, Mucinous, Fibroma, Salivary Gland Neoplasms, Carcinoma, Ductal, Thyroid Neoplasms, Pseudomyxoma Peritonei, Sex Cord-Gonadal Stromal Tumors, Adrenocortical Carcinoma, Carcinoma, Islet Cell, Paget Disease, Extramammary, Vulvar Neoplasms, Rare Diseases, Adenocarcinoma, Papillary, Fibromatosis, Aggressive, Carcinoma, Acinar Cell, Adenocarcinoma, Bronchiolo-Alveolar, Mixed Tumor, Mullerian, Carcinoma, Giant Cell, Paranasal Sinus Neoplasms, Parathyroid Neoplasms, Hydatidiform Mole, Invasive, Pituitary Neoplasms, Neoplasms, Unknown Primary, Odontogenic Tumors

Last Updated: July 22, 2019

Status: Recruiting

Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers


Conditions: Lymphoma, Carcinoma, Colorectal Neoplasms, Carcinoma, Squamous Cell, Lymphoma, Non-Hodgkin, Head and Neck Neoplasms, Hodgkin Disease, Carcinoma, Renal Cell, Endometrial Neoplasms, Mesothelioma, Carcinoma, Transitional Cell, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Carcinoma, Merkel Cell, Carcinoma, Small Cell

Last Updated: July 22, 2019

Status: Recruiting

Ph 2/3 Study in Subjects With MPM w/Low ASS 1 Expression to Assess ADI-PEG 20 With Pemetrexed and Cisplatin


Conditions: Mesothelioma

Last Updated: July 18, 2019

Status: Recruiting

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas


Conditions: Adenocarcinoma, Sarcoma, Mesothelioma

Last Updated: July 17, 2019

Status: Recruiting

Olaparib in People With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: July 13, 2019

Status: Recruiting

Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: July 12, 2019

Status: Recruiting

Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors


Conditions: Colorectal Neoplasms, Head and Neck Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Mesothelioma, Neoplasm Metastasis

Last Updated: July 11, 2019

Status: Recruiting

Phase II Nivolumab and Ramucirumab for Patients With Previously-Treated Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: July 10, 2019

Status: Recruiting

Rapid Autopsy and Procurement of Cancer Tissue


Conditions: Mesothelioma, Urogenital Neoplasms, Thymus Neoplasms

Last Updated: July 4, 2019

Status: Recruiting

Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases


Conditions: Neoplasms, Sarcoma, Mesothelioma, Lung Neoplasms, Esophageal Neoplasms, Neoplasms, Germ Cell and Embryonal, Thymus Neoplasms, Thymoma

Last Updated: July 3, 2019

Status: Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining


Conditions: Esophageal Neoplasms, Mesothelioma, Neoplasms, Lung Neoplasms

Last Updated: June 26, 2019

Status: Recruiting

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma


Conditions: Neoplasms, Mesothelioma, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Biliary Tract Neoplasms

Last Updated: June 25, 2019

Status: Recruiting

BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: June 24, 2019

Status: Recruiting

APG-2449 in Patients With Advanced Solid Tumors


Conditions: Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Mesothelioma

Last Updated: June 20, 2019

Status: Recruiting

Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors


Conditions: Carcinoma, Carcinoma, Squamous Cell, Adenocarcinoma, Mesothelioma, Neuroendocrine Tumors, Nasopharyngeal Carcinoma, Lung Neoplasms, Carcinoma, Neuroendocrine, Adenoma, Islet Cell, Carcinoma, Merkel Cell, Anus Neoplasms

Last Updated: June 11, 2019

Status: Recruiting

Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed


Conditions: Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: May 29, 2019

Status: Recruiting

Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: May 16, 2019

Status: Recruiting

Ex-Vivo Expanded Allogeneic NK Cells For The Treatment Of Pediatric Solid Tumors


Conditions: Neoplasms, Melanoma, Thyroid Diseases, Mesothelioma, Lung Neoplasms, Skin Neoplasms, Bone Neoplasms, Genital Neoplasms, Female, Soft Tissue Neoplasms, Recurrence, Endocrine Gland Neoplasms, Pharyngeal Neoplasms, Mouth Neoplasms, Genital Neoplasms, Male, Thyroid Neoplasms, Urologic Neoplasms, Lip Neoplasms, Sarcoma

Last Updated: May 16, 2019

Status: Recruiting

Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin


Conditions: Mesothelioma, Pleural Diseases

Last Updated: May 15, 2019

Status: Recruiting

Phase 1/2 Trial of TC-210 T Cells in Patients With Advanced Mesothelin-Expressing Cancer


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Cholangiocarcinoma

Last Updated: May 15, 2019

Status: Recruiting

Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies


Conditions: Neoplasms, Peritoneal Neoplasms

Last Updated: May 10, 2019

Status: Recruiting

A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)


Conditions: Neoplasms, Melanoma, Carcinoma, Renal Cell, Mesothelioma, Cholangiocarcinoma

Last Updated: April 30, 2019

Status: Recruiting

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors


Conditions: Carcinoma, Melanoma, Carcinoma, Squamous Cell, Adenocarcinoma, Carcinoma, Hepatocellular, Uterine Cervical Neoplasms, Carcinoma, Renal Cell, Mesothelioma, Breast Neoplasms, Lung Neoplasms, Carcinoma, Transitional Cell, Squamous Cell Carcinoma of Head and Neck, Endometrial Neoplasms, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Esophageal Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma, Anus Neoplasms

Last Updated: April 29, 2019

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-I


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: April 29, 2019

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-II


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: April 29, 2019

Status: Recruiting

Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy


Conditions: Colorectal Neoplasms, Stomach Neoplasms, Esophageal Neoplasms, Mesothelioma, Gastrointestinal Stromal Tumors, Anus Neoplasms, Pancreatic Neoplasms, Liver Neoplasms, Carcinoma, Hepatocellular, Gastrointestinal Neoplasms

Last Updated: April 26, 2019

Status: Recruiting

CAR T Cells in Mesothelin Expressing Cancers


Conditions: Adenocarcinoma, Mesothelioma, Fallopian Tube Neoplasms, Adenocarcinoma of Lung

Last Updated: April 16, 2019

Status: Recruiting

Rehabilitation by Effort for Patients With Advanced Bronchial Cancer


Conditions: Mesothelioma, Carcinoma, Bronchogenic

Last Updated: April 16, 2019

Status: Recruiting

Combination of Immunotherapy and Hyperthermia in Advanced Malignant Mesothelioma


Conditions: Mesothelioma, Fever, Lung Neoplasms

Last Updated: April 15, 2019

Status: Recruiting

Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: April 15, 2019

Status: Recruiting

A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies


Conditions: Carcinoma, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms, Carcinoma, Squamous Cell, Carcinoma, Hepatocellular, Lymphoma, B-Cell, Uterine Cervical Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Small Cell Lung Carcinoma, Lymphoma, Large B-Cell, Diffuse, Endometrial Neoplasms, Mesothelioma, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Merkel Cell, Microsatellite Instability

Last Updated: April 10, 2019

Status: Recruiting

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies


Conditions: Carcinoma, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Carcinoma, Squamous Cell, Neoplasms, Carcinoma, Hepatocellular, Uterine Cervical Neoplasms, Carcinoma, Renal Cell, Esophageal Neoplasms, Small Cell Lung Carcinoma, Mesothelioma, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Squamous Cell Carcinoma of Head and Neck, Stomach Neoplasms, Carcinoma, Merkel Cell, Brain Neoplasms, Neoplastic Syndromes, Hereditary, Colorectal Neoplasms

Last Updated: April 10, 2019

Status: Recruiting

Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: April 4, 2019

Status: Recruiting

Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: March 21, 2019

Status: Recruiting

A Study of ABBV-181 in Participants With Advanced Solid Tumors


Conditions:

Last Updated: March 13, 2019

Status: Recruiting

Safety Study of MGD009 in B7-H3-expressing Tumors


Conditions: Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Pancreatic Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Sarcoma, Thyroid Neoplasms, Mesothelioma, Squamous Cell Carcinoma of Head and Neck

Last Updated: March 5, 2019

Status: Recruiting

Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: February 28, 2019

Status: Recruiting

Dose Individualization of Pemetrexed - IMPROVE-III


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: February 27, 2019

Status: Recruiting

Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Carcinomatosis Diagnosis


Conditions: Carcinoma

Last Updated: February 19, 2019

Status: Recruiting

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers


Conditions: Mesothelioma

Last Updated: February 9, 2019

Status: Recruiting

Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Neoplasms, Fibrous Tissue, Solitary Fibrous Tumors, Solitary Fibrous Tumor, Pleural, Pleural Neoplasms

Last Updated: February 5, 2019

Status: Recruiting

Staging Procedures to Diagnose Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Neoplasms, Fibrous Tissue, Solitary Fibrous Tumors, Solitary Fibrous Tumor, Pleural, Pleural Neoplasms

Last Updated: February 5, 2019

Status: Recruiting

Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Neoplasms, Fibrous Tissue, Solitary Fibrous Tumors, Solitary Fibrous Tumor, Pleural, Pleural Neoplasms

Last Updated: February 5, 2019

Status: Recruiting

TILs & Low-Dose IL-2 Therapy Following Cyclophosphamide and Fludarabine in Pleural Mesothelioma Patients


Conditions: Mesothelioma

Last Updated: February 1, 2019

Status: Recruiting

Mesothelioma Stratified Therapy (MiST) : A Multi-drug Phase II Trial in Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: January 31, 2019

Status: Recruiting

MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 15, 2019

Status: Recruiting

Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study


Conditions: Lymphoma, Lymphoma, Follicular, Sarcoma, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Mesothelioma, Sarcoma, Synovial, Rhabdoid Tumor, Kidney Neoplasms, Teratoma

Last Updated: January 8, 2019

Status: Recruiting

Intrapleural Cryotherapy for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 7, 2019

Status: Recruiting

Accelerated Hypofractionated Radiotherapy in the Treatment of Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: November 8, 2018

Status: Recruiting

Integrated Cancer Repository for Cancer Research


Conditions: Neoplasms, Multiple Myeloma, Pancreatic Neoplasms, Urinary Bladder Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Endometrial Neoplasms, Thyroid Neoplasms, Mesothelioma, Kidney Neoplasms, Carcinoma, Renal Cell, Skin Neoplasms, Salivary Gland Neoplasms, Anus Neoplasms, Gallbladder Neoplasms, Bile Duct Neoplasms, Cholangiocarcinoma, Oropharyngeal Neoplasms, Urethral Neoplasms, Nasopharyngeal Neoplasms, Nasopharyngeal Carcinoma, Vaginal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Adenomatous Polyposis Coli, Testicular Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Intestinal Neoplasms, Hypopharyngeal Neoplasms, Penile Neoplasms, Ureteral Neoplasms, Breast Neoplasms, Peritoneal Neoplasms, Paranasal Sinus Neoplasms, Duodenal Neoplasms, Neoplasms, Unknown Primary, Lip Neoplasms, Thymus Neoplasms

Last Updated: November 1, 2018

Status: Recruiting

Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed


Conditions: Mesothelioma, Carcinoma, Fever, Peritoneal Neoplasms, Pseudomyxoma Peritonei

Last Updated: October 15, 2018

Status: Recruiting

Screening of Alberta Asbestos Exposed Workers for Lung Cancer and Mesothelioma


Conditions: Lung Neoplasms, Mesothelioma

Last Updated: October 10, 2018

Status: Recruiting

Mesothelioma and Radical Surgery 2


Conditions: Mesothelioma

Last Updated: October 8, 2018

Status: Recruiting

Short Neoadjuvant Hemithoracic IMRT for MPM


Conditions: Mesothelioma

Last Updated: September 21, 2018

Status: Recruiting

Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma


Conditions: Adenocarcinoma, Mesothelioma, Carcinoma, Ovarian Epithelial

Last Updated: September 19, 2018

Status: Recruiting

A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549


Conditions: Carcinoma, Non-Small-Cell Lung, Melanoma, Mesothelioma, Triple Negative Breast Neoplasms, Neoplasms, Squamous Cell, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Adrenocortical Carcinoma

Last Updated: September 11, 2018

Status: Recruiting

Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies


Conditions: Leukemia, Colorectal Neoplasms, Multiple Myeloma, Pancreatic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Lymphoid, Mesothelioma, Sarcoma, Synovial, Burkitt Lymphoma, Esophageal Neoplasms, Carcinoma, Renal Cell, Kidney Neoplasms

Last Updated: August 17, 2018

Status: Recruiting

Nintedanib as Switch Maintenance Treatment of Pleural Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: August 13, 2018

Status: Recruiting

DENdritic Cell Immunotherapy for Mesothelioma


Conditions: Mesothelioma

Last Updated: July 31, 2018

Status: Recruiting

CheckpOiNt Blockade For Inhibition of Relapsed Mesothelioma


Conditions: Mesothelioma

Last Updated: July 23, 2018

Status: Recruiting

Pleurectomy/ Decortication (P/D) Preceded or Followed by Chemotherapy in Patients With Early Stage MPM


Conditions: Mesothelioma

Last Updated: July 11, 2018

Status: Recruiting

Autologous Dendritic Cell Vaccination in Mesothelioma


Conditions: Mesothelioma

Last Updated: May 22, 2018

Status: Recruiting

Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers


Conditions: Lung Neoplasms, Mesothelioma

Last Updated: March 22, 2018

Status: Recruiting

Study of FAK (Defactinib) and PD-1 (Pembrolizumab) Inhibition in Advanced Solid Malignancies (FAK-PD1)


Conditions: Mesothelioma, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms

Last Updated: March 16, 2018

Status: Recruiting

Confocal Laser Endomicroscopy in Pleural Malignancies


Conditions: Mesothelioma, Thymoma, Pleural Diseases

Last Updated: September 20, 2017

Status: Recruiting

Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors


Conditions: Uterine Cervical Neoplasms, Urinary Bladder Neoplasms, Mesothelioma, Carcinoma, Non-Small-Cell Lung, Thymoma, Thymus Neoplasms

Last Updated: August 22, 2017

Status: Recruiting

Intracavitary Cisplatin-Fibrin Localized Chemotherapy After P/D or EPP for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: August 22, 2017

Status: Recruiting

uPAR-PET for Prognostication in Patients With Non-small Cell Lung Cancer, Malignant Pleural Mesothelioma and Large Cell Neuroendocrine Carcinoma of the Lung


Conditions: Carcinoma, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Carcinoma, Neuroendocrine

Last Updated: November 18, 2016

Status: Recruiting

Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies


Conditions: Carcinoma, Neoplasms, Mesothelioma, Colorectal Neoplasms, Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Pseudomyxoma Peritonei, Peritoneal Neoplasms

Last Updated: October 14, 2015

Status: Recruiting

Written By

Linda Molinari Editor in Chief

Linda Molinari has more than 15 years of experience as a writer and advocate for mesothelioma patients and a ban on asbestos.


Full Bio Editorial Guidelines
Reviewed By

Annette Charlevois Patient Support Coordinator

Annette Charlevois is a senior paralegal at the law firm of Early, Lucarelli, Sweeney & Meisenkothen, helping patients find medical and legal resources.


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