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Testicular Mesothelioma

Testicular mesothelioma develops in the tunica vaginalis testis, the membrane lining the testes. This is the rarest of the four main types of mesothelioma, accounting for less than 1% of all mesothelioma diagnoses with only about 100 reported cases.

Testicular mesothelioma, or malignant mesothelioma of the tunica vaginalis, lacks substantial research due to a limited number of cases. Unlike other forms of mesothelioma, the cause of this type is unclear, with studies noting 41% of reported cases being linked to asbestos exposure. In other cases, researchers note past trauma, prolonged fluid buildup in the groin or a prior hernia repair could help lead to a testicular mesothelioma diagnosis. Due to its rarity, how the disease progresses and life expectancy are still unclear.

What is the Prognosis for Testicular Mesothelioma?

Testicular mesothelioma has generally shown a better prognosis than other forms of the disease because it is more localized, and several documented instances of mesothelioma of the tunica vaginalis have been benign. Researchers have found the median survival is typically around 20 – 23 months, though some patients have lived years after being diagnosed. This is better than other forms of mesothelioma with a life expectancy of only about one year to 21 months.

Several factors can influence an individual patient’s prognosis, including:

Like with other types of mesothelioma, the cancerous cells show an aggressive growth rate and the potential to metastasize quickly. Additionally, there is a high risk of recurrence. One study found the recurrence rate was at least 53%, with at least 60% occurring within two years after successful treatment. For those with recurrent testicular mesothelioma, research suggests an average life expectancy of about 14 months.

Testicular Mesothelioma Symptoms

Similar to pleural mesothelioma and peritoneal mesothelioma, most testicular mesothelioma patients display nonspecific symptoms easily attributed to other conditions and diseases, like an inguinal hernia or other testicular cancers. Doctors have also seen asymptomatic cases with diagnosis stemming from a routine physical examination.

Sometimes, testicular mesothelioma tumors may be secondary in nature and have been linked to peritoneal mesothelioma metastasis in a few cases. In these instances, patients may experience more symptoms impacting the abdomen, like abdominal pain or swelling. Researchers have also noted that some of the common symptoms, like prolonged hydrocele, may also help lead to a testicular mesothelioma diagnosis.

Common Symptoms of Testicular Mesothelioma
  • A lump or mass on the testicle
  • Hydrocele (fluid buildup in the scrotum causing swelling)
  • Pain in the testes
  • Inflammation of the epididymis (epididymitis)

How Is Testicular Mesothelioma Diagnosed?

After a patient presents symptoms or a testicle irregularity is found upon examination, a doctor will order image testing, likely an ultrasound. A testicular mesothelioma ultrasound is a non-invasive, low-risk procedure that uses sound waves to create a picture of the scrotum. The ultrasound may show any swelling like hydrocele or masses that may have developed. Studies have suggested that about 56% of testicular mesothelioma patients present hydrocele, while about 33% present some solid mass in the testes.

Resources for Testicular Mesothelioma Patients

Following an ultrasound, a doctor will likely take a blood test or assay to help determine the cause of symptoms and hopefully offer early detection of any cancer. For mesothelioma specifically, there are a number of biomarkers in the blood that doctors can look for to help detect the asbestos cancer early, including calretinin, cytokeratin 5/6 and Wilms’ tumor gene 1 (WT1), which are often expressed by mesothelioma tumors.

Though a blood test can suggest a mesothelioma diagnosis, the only definitive way to diagnose the cancer is through a tissue biopsy. The biopsy will usually be the last step of the diagnostic process, and will determine cell type and staging. This will then offer insight into a patient’s prognosis. Additional tests may be performed to better determine metastasis to the lymph nodes or other parts of the body and secondary tumors.

Testicular Mesothelioma Stages

Understanding the stage of cancer is an important aspect in determining a patient’s prognosis and developing an appropriate treatment plan. Since this form of mesothelioma is so rare, doctors do not have enough data to develop a proper staging system. Instead, doctors will use general mesothelioma characteristics to determine how advanced a patient’s case is and how it might be expected to progress.

Stage 1 or stage 2 testicular mesothelioma indicate a localized tumor. With limited or no cancer growth, patients will have more treatment options, like surgical resection. As the cancer becomes more advanced and spreads to the lymph nodes and other organs, treatment options are more limited and prognosis worsens.

Testicular Mesothelioma Treatment

Testicular mesothelioma has most commonly been treated with a multimodal approach that combines surgery, chemotherapy and radiation therapy. Whether or not to pursue aggressive mesothelioma treatment will be largely determined by if the disease is still localized or has metastasized. Treatment options will be more limited as the cancer becomes more advanced.

Researchers have found that an optimal treatment for localized disease consists of a radical inguinal orchiectomy, a surgical procedure that removes one or both testicles and the spermatic cord. This surgery is considered the standard of care for all testis cancers, though there are some testis-sparing options available for some patients. Since studies have shown testicular mesothelioma often only affects one testicle when localized, a less aggressive surgery may be an option for some patients. However, one study found the recurrence rate dropped by nearly 25% for those patients who opted for the more radical surgery.

Chemotherapy alone or combined with radiation therapy is another option for patients with advanced disease, and may sometimes be utilized in combination with surgery. Since it is so rare, researchers remain unsure of the best chemotherapy options for testicular mesothelioma. In the documented case reports, most patients were treated with the standard of care, Alimta and cisplatin. Chemotherapy in combination with radiation may also be a good option for patients who experience recurrent testicular mesothelioma. Ultimately, patients will need to seek professional medical advice for their specific case.

Author: Linda Molinari

Editor in Chief, Mesothelioma Cancer Alliance

Linda Molinari

Reviewer: Annette Charlevois

Patient Support Coordinator

Annette Charlevois
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Sources

Akin Y, Bassorgun I, et al. Malignant mesothelioma of tunica vaginalis: an extremely rare case presenting without risk factors. Singapore Medical Journal. March 2015; 56(3): e53–e55. doi: 10.11622/smedj.2015053

Al-Qahtani M, Morris B, et al. Malignant mesothelioma of the tunica vaginalis. The Canadian Journal of Urology. Apr 2007; 14 (2): 3514-3517.

Chekol S, Sun C. Malignant mesothelioma of the tunica vaginalis testis diagnostic studies and differential diagnosis. Archives of Pathology & Laboratory Medicine. January 2012; 136: 1137-117.

Priyadarshi N, Bhat S, Paul F, et al. Malignant Mesothelioma of Testis: A Report of Three Cases and Review of Literature. Medical Journal of Dr. D.Y. Patil Vidyapeeth. May 3018;11(1):60-62.

Plas E, Riedl C, et al. Malignant mesothelioma of the tunica vaginalis testis. Cancer. November 1998; 83: 2437‐2446.

Sevilla C, Salvador C, et al. Two case reports of benign testicular mesothelioma and review of the literature. Case Reports in Oncological Medicine. June 2016. doi: 10.1155/2017/5419635

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