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Mesothelioma Research

Mesothelioma Research

In an attempt to consolidate important articles and research related to the diagnosis and treatment of mesothelioma, we have added this section to our Web site. The research articles below include diagnostic studies, review studies, case studies, etiological studies, and therapy studies. The research articles are sorted by date descending. We have also included relevant mesothelioma related press releases and doctor interviews. Someday we hope to be able to report a cure for mesothelioma here.

Boehringer Ingelheim’s Nintedanib Shows Promise as a New Treatment for Malignant Pleural Mesothelioma

January 9, 2018

Boehringer Ingelheim’s nintedanib has been granted PIM—Promising Innovative Medicine—status for the treatment of malignant pleural mesothelioma (MPM) in the United Kingdom (UK) by the country’s Medicine and Healthcare Products Regulatory Agency.

CRISPR Gene-Editing Technology and Immunotherapy — Will This Be the Next Revolution in Cancer Treatment?

June 21, 2016

The first human trial involving CRISPR gene-editing technology was approved by the National Institutes of Health (NIH) advisory panel.

Mesothelioma Avastin® Cisplatin Pemetrexed Study (MAPS): New Triplet Therapy Shows Significant Improvement in Overall Survival (OS) in Patients with Malignant Pleural Mesothelioma

March 31, 2016

A study examining a new triplet therapy of Avastin®, cisplatin, and pemetrexed showed significant improvement in overall survival (OS) in patients with malignant pleural mesothelioma.

Releasing the Brakes on Cancer Immunotherapy

N Engl J Med. 2015 Oct 15;373(16):1490-2.

Ribas's article, entitled "Releasing the Brakes on Cancer Immunotherapy," discusses the evolution of the potential of the human body's immune system in fighting cancer.

Probability of Cancer in Pulmonary Nodules Detected on First Screening CT

New England Journal of Medicine, September 5, 2013

The U.S. National Lung Screening Trial showed that screening with the use of low-dose thoracic computed tomography (CT) reduces mortality from lung cancer by 20%

Heated Intraoperative Intraperitoneal Chemotherapy Developed by Renowned Surgeon
April 29, 2008

Dr. Paul Sugarbaker, renowned oncologic surgeon specializing in mesothelioma at the Washington Cancer Institute, developed a leading-edge surgical procedure to treat mesothelioma called heated intraoperative intraperitoneal chemotherapy.

ASCO: Recent Study Confirms Pemetrexed-Platinum Activity in Malignant Mesothelioma

By Peggy Peck, Managing Editor, MedPage Today, June 06, 2007

Confirming results of previous studies, pemetrexed combined with either cisplatin or carboplatin demonstrated activity in previously untreated malignant pleural mesothelioma, said researchers.

Perineural Spread of Malignant Mesothelioma Resulting in an Intradural Spinal Cord Mass

J Neurooncol. 2007 Jan;81(2):185-9

Spinal cord involvement by perineural spread of malignant mesothelioma is rare.

Current Problems in the Diagnosis of Malignant Pleural Mesothelioma

Kyobu Geka. 2007 Jan;60(1):14-8

The diagnosis of malignant pleural mesothelioma (MPM) is challenging although MPM is highly aggressive tumor.

Sex Difference in Diffuse Malignant Peritoneal Mesothelioma

Br J Surg. 2006 Dec;93(12):1536-42

Diffuse malignant peritoneal mesothelioma (DMPM) is rare and in the past has proved an invariably fatal disease.

Malignant Pleural Mesothelioma: A Comprehensive Review

Cancer Control. 2006 Oct;13(4):255-63

The incidence of malignant mesothelioma continues to increase, but the disease remains difficult to detect early and treat effectively.

Mesothelioma in Patients with Nonoccupational Asbestos Exposure. An Evidence-based Approach to Causation Assessment

Ann Diagn Pathol. 2006 Aug;10(4):241-50

The specific parameters of nonoccupational asbestos exposures (NOAE) that can distinguish an idiopathic from an asbestos-caused malignant mesothelioma (MM) are controversial.

FDA approves Alimta®-Cisplatin Combination for treatment of Asbestos-Related Cancer

Press Release February 2, 2004

The first and only drug regimen proven to help patients with an asbestos cancer live longer was approved today by the U.S. Food and Drug Administration.

Eli Lilly Boosted by Mesothelioma Treatment Drug Alimta®

Financial Times 2002 May.

Alimta®, a new type of cancer treatment being developed by Eli Lilly, is the first treatment to significantly improve mesothelioma prognosis and ameliorate the symptoms of the disease.

Older Mesothelioma Research and Treatment Alerts

Malignant Pleural Mesothelioma in Pregnancy

A 37-year-old pregnant woman presented at 18 weeks' gestation with unrelenting chest and shoulder pain, massive pleural effusion, and a large thoracic mass.

Mesothelioma and Lung Tumors Attributable to Asbestos Among Petroleum Workers

Asbestos exposure has been definitively found to be associated with both mesothelioma and lung cancer. Nevertheless, in the overall population of oil refinery workers potentially exposed to asbestos, many studies clearly show a definitely increased risk of mesothelioma, but no proven excess of lung cancer after comparison to the general population.

Prognostic Value of FDG PET Imaging in Malignant Pleural Mesothelioma

The purpose of this study was to assess whether tumor metabolic activity, as assessed by fluorodeoxyglucose (FDG) PET imaging, correlates inversely with survival.

Environmental Exposure to Asbestos in Asbestos Cement Workers: A Case of Additional Exposure from Indiscriminate Use of Industrial Wastes

The paper presents data on cancer risk, especially pleural mesothelioma and lung cancer, among the workers of asbestos cement plant who living in the vicinity of the plant, were also environmentally exposed to asbestos.

Tyler Asbestos Workers: Mortality Experience in a Cohort Exposed to Amosite

This study examines the causes of death among 1130 former workers of a plant in Tyler, Texas dedicated to the manufacture of asbestos pipe insulation materials.

Photodynamic Therapy (PDT) of Malignant Mesothelioma of Pleura

The LumaCare™ site provides an abstract and details of a recent study entitled "Photodynamic Therapy of Malignant Mesothelioma of Pleura". The study was conducted at the Norwegian Radium Hospital.

Author: Linda Molinari

Editor in Chief, Mesothelioma Cancer Alliance

Linda Molinari

Reviewer: Annette Charlevois

Patient Support Coordinator

Annette Charlevois



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