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Mesothelioma Survival Rate

Approximately 55% of mesothelioma patients live longer than six months, while roughly 35% live longer than one year. Only 9% survive longer than five years. Testicular and peritoneal patients typically see the best survival rates, followed by pleural and pericardial mesothelioma.

Cancer survival rates are typically measured with 5-year statistics, but mesothelioma statistics often reference 1-year and 3-year statistics due to a poor prognosis. Survival rates can help patients better understand their prognosis and also help specialists identify potential risk factors driving patient life expectancy. Survival time varies for mesothelioma patients based on type, age, treatment and other factors.

Mesothelioma Survival Rate by Type Life Expectancy by Mesothelioma Cell Type
Pleural Peritoneal Pericardial
1 year 73% 92% 51%
3 years 23% 74% 26%
5 years 12% 65% 23%
10 years 4.7% 39% (N/A)

Survival Statistics

Survival rate references a number of people that survived for a certain amount of time after their diagnosis. Survival rate is different from life expectancy in that life expectancy refers to the average length of time patients with mesothelioma live. Life expectancy is usually referenced in years or months and depends on a variety of factors like staging, mesothelioma location, cell type and patient characteristics. Together, both of these statistics can provide information about an individual’s prognosis.

Mortality rate is another term frequently used alongside survival rate. Mortality rate is a statistic used by health organizations and governmental agencies to understand the prevalence of a disease in a particular population, such as a certain age group or sex. This can help determine potential risk factors for the development, progression and life expectancies for malignant mesothelioma.

Survival Rates for Mesothelioma

In recent years, mesothelioma survival rates have improved, particularly for pleural and peritoneal mesothelioma. New diagnostic methods to detect the disease early, as well as new treatments, are helping cancer patients live longer. However, there are many factors that can influence survival rates that must be taken into account, such as age, gender, type and other patient characteristics.

Age and Gender

Mesothelioma survival rates largely depend on the patient’s age and gender. On average, younger patients have a higher 5-year survival rate than older patients, and women have better overall survival rates than men. Mesothelioma specialists and researchers believe this is due to the overall better health of younger individuals, whereas older patients tend to have other diseases and conditions that could complicate their health and ability to withstand treatment. In relation to gender, more men held asbestos occupations at the height of its use, resulting in higher amounts of long-term exposure.

5-Year Mesothelioma Survival Rate by Age and Sex Life Expectancy by Age and Sex
Age at Diagnosis Male Female
Ages <45 34.8% 54.1%
Ages 45 - 54 17.3% 27.5%
Ages 55 - 64 10.4% 17.6%
Ages 65 - 74 6.6% 13%
Ages 75+ 2.9% 5.2%

Staging

The stage of mesothelioma at the time of diagnosis is also an influential factor to survival rates. Early detection is the best way to improve a patient’s mesothelioma prognosis, and early-stage diagnoses have substantially higher survival rates than late-stage diagnoses. When diagnosed at stage 3 or stage 4, the cancer has likely spread to distant areas of the body and is therefore more difficult to target and treat. If diagnosed at stage 1 or 2, the disease is likely localized and can be targeted with surgical resection and other aggressive treatments.

Other Factors

In addition to age, gender and staging, there are a variety of other factors that impact survival rates, including:

Ultimately, patients should discuss their individual diagnosis with their physician, along with impacting factors, to better understand where they fall in terms of survival.

Improving Mesothelioma Survival

Though there are many factors that can negatively impact survival rates, there are also ways that patients can improve their survival after being diagnosed with mesothelioma. Treatment is the most important factor in extending life expectancy following diagnosis. For instance, a newer treatment combination of surgery with a heated chemotherapy wash known as hyperthermic intraperitoneal chemotherapy (HIPEC) has improved 5-year peritoneal mesothelioma survival rates to at least 50%. Other types of mesothelioma have also seen some improvement in survival, as clinical trials continue to show hope in improving prognosis with treatments like immunotherapy.

Mesothelioma Survival Rate by Treatment Type Mesothelioma Survival Rate by Treatment Type
Pleural Mesothelioma
Chemotherapy Only 2 years 19%
5 years 4%
Pleurectomy / Decortication (P/D) 2 years 40%
5 years 10%
Extrapleural Pneumonectomy (EPP) 2 years 37%
5 years 12%
Peritoneal Mesothelioma
CRS-207 + Hyperthermic Intraperitoneal Chemotherapy (HIPEC) 5 years 50%

The treatment options available are largely dependent on the type and stage of mesothelioma. For those with stage 1 or stage 2 mesothelioma, undergoing aggressive treatment to remove tumors and tissues or organs containing cancer cells can lead to higher survival rates. Those with a later stage diagnosis may not have the same surgical options available, as the cancer has spread to the lymph nodes or distant organs. However, chemotherapy or radiation therapy treatments could still be beneficial and extend survival.

Pleural mesothelioma patients who undergo aggressive pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP) surgeries, both common in multimodal treatment plans, generally have a much higher rate of survival than those who receive chemotherapy alone. For peritoneal mesothelioma, patients who undergo cytoreductive surgery (CRS) with HIPEC have significantly higher rates of survival compared to patients who are unable to undergo surgery. When combined with systemic chemotherapy as an adjuvant treatment, the 5-year survival rate of patients who undergo CRS + HIPEC can be as high as 67%.

In addition to traditional aggressive mesothelioma treatments, patients may choose to find clinical trials or undergo alternative treatments to extend their life expectancy, along with improving and maintaining better overall health.

Mesothelioma Survivors

Mesothelioma survival rates can provide patients with a general outlook on survival, but don’t define individual cases. Advances in diagnostic tools and treatment techniques have lengthened life expectancies and improved survival rates for mesothelioma patients, while also helping contribute to long-term mesothelioma survivorship.

  • Heather Von St. James: Heather defied her 15-month prognosis after undergoing aggressive surgery to remove her cancer. A mesothelioma survivor, Heather uses her experience to offer hope as she advocates for awareness and a full asbestos ban.
  • Mavis Nye: Mavis defied her 3-month life expectancy after partaking in a clinical trial using a new immunotherapy drug, Keytruda. She continues to advocate for asbestos awareness and help others diagnosed with mesothelioma, seen through her creation of the Mavis Nye Foundation.
  • Paul Cowley: Paul faced a malignant pleural mesothelioma diagnosis with 12 – 24 months to live, but overcame this prognosis after undergoing two aggressive surgeries in a six-month span to remove his tumors and affected surrounding tissues. Paul and his family continue to raise awareness about mesothelioma and the dangers of asbestos exposure.

Speak with a MESOTHELIOMA SURVIVOR

Von St. James Family

Coordinate a time to speak with Heather Von St. James.

Learn Firsthand About:

  • Heather’s Amazing Story
  • Dr. David Sugarbaker’s Successful Treatment Approach
  • Life After Surviving a Mesothelioma Diagnosis
  • Coping Strategies for Patients & Family Members

These stories show the value in aggressive treatments and emerging techniques. Their stories and the stories of other mesothelioma survivors continue to offer hope to those diagnosed with this disease.

Author: Linda Molinari

Editor in Chief, Mesothelioma Cancer Alliance

Linda Molinari

Reviewer: Annette Charlevois

Patient Support Coordinator

Annette Charlevois
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Sources

American Cancer Society. Learn About Cancer: Malignant Mesothelioma.

Baumann F, Flores E, et al. Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival. Cancer Research. 2015;76(2):206-215. doi: 10.1093/carcin/bgu227

Faig J, Howard S, et al. Changing Pattern in Malignant Mesothelioma Survival. Translational Oncology. February 2015;8(1):35-39. doi: 10.1016/j.tranon.2014.12.002

Hassan R and Ho M. Mesothelin Targeted Cancer Immunotherapy. European Journal of Cancer. January 2008;44(1):46-53. doi: 10.1016/j.ejca.2007.08.028

Kepenekian V, Elias D, Passot G, et al. Diffuse malignant peritoneal mesothelioma: Evaluation of systemic chemotherapy with comprehensive treatment through the RENAPE Database: Multi-Institutional Retrospective Study. European Journal of Cancer. September 2016;65:69-79. doi: 10.1016/j.ejca.2016.06.002

Milano MT and Zhang H. Malignant Pleural Mesothelioma: A Population-Based Study of Survival. Journal of Thoracic Oncology. November 2010;5(11):1841-1848. doi: 10.1097/JTO.0b013e3181f1cf2b

SEER Cancer Statistics Review 1975-2013. National Cancer Institute.

Oliveira GH, Al-Kindi S, Hoimes C, et al. Characteristics and Survival of Malignant Cardiac Tumors: A 40-Year Analysis of Over 500 Patients. Circulation. October 2015;132:2395-2402. doi: 10.1161/CIRCULATIONAHA.115.016418

Sciarrillo R, Gomez VE, Pennati M, et al. Abstract 332: Spliceosome inhibition as novel strategy against diffuse malignant peritoneal mesothelioma. Cancer Research. July 2016;76(14):Abstract nr 332. doi: 10.1158/1538-7445.AM2016-332

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