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Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Carcinomatosis Diagnosis

Brief Summary

Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). It was first used in gastroenterology and came later to the light in pulmonary medicine and is still an experimental technique. In gastroenterology, this new investigational technique is used in Barret oesophagus, inflammatory bowel disease, pancreas cystic lesions... Nowadays, there are no data concerning usefullness of endomicroscopy in medical thoracoscopy. During thoracoscopy This new tool could help to target biopsies or help clinicians to do the right diagnosis early, allowing rapid therapeutic intervention (talc pleurodesis for example) . Furthermore, some details can be studied only during live imaging as microorganisms or bloodflows. We performed an endomicroscopy to every patient needing a thoracoscopy (no matter the indication) and who agreed to participate. We Compared endomicroscopy diagnosis and pathologic diagnosis to assess the ability of this new tool to diagnose a pleural carcinomatosis.

Tracking Information
First Received DateJanuary 13, 2019
Last Changed DateJanuary 15, 2019
Start DateMay 22, 2018
Anticipated Primary Completion DateDecember 20, 2019
Primary Outcome Measures

Pleural carcinomatosis identification (compared to standard biopsies) [Time Frame: One day.]

Descriptive Information
Study TypeObservational
Condition
  • Pleural Carcinomatosis
Intervention
  • Device: Study of the pleural cavity with a confocal laser endomicroscope.
Study Arms / Comparison Groups0 / 1
Recruitment Information
Recruitment StatusRecruiting
Anticipated Enrollment60
GenderAll
Ages18 Years - N/A
Accepts Healthy VolunteersNo
Contact Olivier Bonhomme, MD
Email: obonhomme@chuliege.be
Phone: 003243667881
Eligibility Criteria

Inclusion Criteria:

- Every patient refered for a medical thoracoscopy and willing to participate.

Exclusion Criteria:

- < 18 ans

Administrative Information
NCTIDNCT03805971
Responsible PartyPrincipal Investigator
SponsorUniversity Hospital of Liege
Verification DateJanuary 2019
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