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HomeTreatmentClinical TrialsClinical Trials – Not Recruiting

Provided below is a list of the clinical trials that are currently in progress to evaluate new mesothelioma treatment protocols. Please note that the enrollment period for the following mesothelioma studies has concluded and no new participants are being recruited at this time.

The purpose of these studies is to determine both the safety and effectiveness of new mesothelioma drugs and treatment therapies. Click on a link to learn more about a study and to get recent update information.

PembROlizuMab Immunotherapy Versus Standard Chemotherapy for Advanced prE-treated Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: July 19, 2019

Status: Active, not recruiting

Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: July 2, 2019

Status: Active, not recruiting

Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma


Conditions: Mesothelioma

Last Updated: June 26, 2019

Status: Active, not recruiting

Early Palliative Care in Advanced Lung and Gastrointestinal Malignancies


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Esophageal Neoplasms, Small Cell Lung Carcinoma, Liver Neoplasms, Mesothelioma

Last Updated: June 20, 2019

Status: Active, not recruiting

Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: June 19, 2019

Status: Active, not recruiting

Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: June 17, 2019

Status: Active, not recruiting

A Study of LY3023414 in Participants With Advanced Cancer


Conditions: Carcinoma, Non-Small-Cell Lung, Lymphoma, Non-Hodgkin, Neoplasms, Mesothelioma, Neoplasm Metastasis

Last Updated: June 16, 2019

Status: Active, not recruiting

Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)


Conditions: Mesothelioma

Last Updated: June 6, 2019

Status: Active, not recruiting

Phase II Study of Adjuvant WT-1 Analog Peptide Vaccine in MPM Patients After MSK10-134


Conditions: Mesothelioma

Last Updated: May 9, 2019

Status: Active, not recruiting

Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: May 9, 2019

Status: Active, not recruiting

Psychosocial Needs and Exploration of Online Support for Patients With Mesothelioma


Conditions: Mesothelioma

Last Updated: May 7, 2019

Status: Active, not recruiting

INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies


Conditions: Neoplasms, Neoplasm Metastasis

Last Updated: May 6, 2019

Status: Active, not recruiting

A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas


Conditions: Lymphoma

Last Updated: May 3, 2019

Status: Active, not recruiting

Vinorelbine in Mesothelioma


Conditions: Mesothelioma

Last Updated: April 29, 2019

Status: Active, not recruiting

Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: April 10, 2019

Status: Active, not recruiting

Clinical Study of YS110 in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: March 29, 2019

Status: Active, not recruiting

Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin


Conditions: Carcinoma, Carcinoma, Hepatocellular, Mesothelioma, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

Last Updated: March 18, 2019

Status: Active, not recruiting

Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: March 13, 2019

Status: Active, not recruiting

Gene Therapy for Pleural Malignancies


Conditions: Mesothelioma, Pleural Effusion

Last Updated: March 4, 2019

Status: Active, not recruiting

Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: March 4, 2019

Status: Active, not recruiting

Clinical and Histopathologic Characteristics of BAP1 Mutations


Conditions: Melanoma, Carcinoma, Renal Cell, Mesothelioma, Cholangiocarcinoma, Uveal Neoplasms

Last Updated: February 28, 2019

Status: Active, not recruiting

Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: February 28, 2019

Status: Active, not recruiting

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Esophageal Neoplasms, Anxiety Disorders, Small Cell Lung Carcinoma, Liver Neoplasms, Mesothelioma, Bile Duct Neoplasms, Cholangiocarcinoma

Last Updated: February 26, 2019

Status: Active, not recruiting

Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients


Conditions: Mesothelioma

Last Updated: February 25, 2019

Status: Active, not recruiting

Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent


Conditions: Mesothelioma

Last Updated: February 11, 2019

Status: Active, not recruiting

Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion


Conditions: Mesothelioma, Pleural Effusion, Pleural Effusion, Malignant

Last Updated: February 1, 2019

Status: Active, not recruiting

Ganetespib With Platinum, in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 30, 2019

Status: Active, not recruiting

Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma


Conditions: Mesothelioma, Pleural Effusion, Vaccinia, Pleural Effusion, Malignant

Last Updated: January 17, 2019

Status: Active, not recruiting

Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: January 16, 2019

Status: Active, not recruiting

Safety and Efficacy of Listeria in Combination With Chemotherapy as Front-line Treatment for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 8, 2019

Status: Active, not recruiting

Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Pleural Effusion

Last Updated: January 2, 2019

Status: Active, not recruiting

ATREUS - Phase II Study on the Activity of Trabectedin in Patients With Malignant Pleural Mesothelioma (MPM)


Conditions: Mesothelioma

Last Updated: December 6, 2018

Status: Active, not recruiting

Ipilimumab and Nivolumab in the Treatment of Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: October 31, 2018

Status: Active, not recruiting

Lurbinectedin Monotherapy in Patients With Progressive Malignant Pleural Mesothelioma.


Conditions: Mesothelioma

Last Updated: October 25, 2018

Status: Active, not recruiting

Dasatinib in Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 26, 2018

Status: Active, not recruiting

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors


Conditions: Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Mesothelioma, Triple Negative Breast Neoplasms, Gastrointestinal Stromal Tumors

Last Updated: July 18, 2018

Status: Active, not recruiting

Pembrolizumab in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: March 1, 2018

Status: Active, not recruiting

Observational Prospective Analysis of Biological Characteristics of Mesothelioma Patients


Conditions: Mesothelioma

Last Updated: October 31, 2017

Status: Active, not recruiting

French National Registry of Rare Peritoneal Surface Malignancies


Conditions: Neoplasms, Mesothelioma, Desmoplastic Small Round Cell Tumor, Cystadenocarcinoma, Serous, Pseudomyxoma Peritonei, Peritoneal Neoplasms, Leiomyomatosis

Last Updated: August 18, 2017

Status: Active, not recruiting

Written By

Linda Molinari Editor in Chief

Linda Molinari has more than 15 years of experience as a writer and advocate for mesothelioma patients and a ban on asbestos.


Full Bio Editorial Guidelines
Reviewed By

Annette Charlevois Patient Support Coordinator

Annette Charlevois is a senior paralegal at the law firm of Early, Lucarelli, Sweeney & Meisenkothen, helping patients find medical and legal resources.


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