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Provided below is a list of the clinical trials that are currently in progress to evaluate new mesothelioma treatment protocols. Please note that the enrollment period for the following mesothelioma studies has concluded and no new participants are being recruited at this time.

The purpose of these studies is to determine both the safety and effectiveness of new mesothelioma drugs and treatment therapies. Click on a link to learn more about a study and to get recent update information.

A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors


Conditions: Neoplasms

Last Updated: November 6, 2020

Status: Active, not recruiting

Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.


Conditions: Neoplasms

Last Updated: November 2, 2020

Status: Active, not recruiting

Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: October 30, 2020

Status: Active, not recruiting

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies


Conditions: Carcinoma, Merkel Cell, Carcinoma, Lung Neoplasms, Melanoma, Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma, Mesothelioma, Triple Negative Breast Neoplasms, Squamous Cell Carcinoma of Head and Neck

Last Updated: October 28, 2020

Status: Active, not recruiting

MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: October 19, 2020

Status: Active, not recruiting

Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma


Conditions: Mesothelioma

Last Updated: October 1, 2020

Status: Active, not recruiting

Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 4, 2020

Status: Active, not recruiting

Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors


Conditions: Carcinoma, Renal Cell, Mesothelioma

Last Updated: September 2, 2020

Status: Active, not recruiting

Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: August 19, 2020

Status: Active, not recruiting

Lurbinectedin Monotherapy in Patients With Progressive Malignant Pleural Mesothelioma.


Conditions: Mesothelioma

Last Updated: August 18, 2020

Status: Active, not recruiting

PembROlizuMab Immunotherapy Versus Standard Chemotherapy for Advanced prE-treated Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: August 10, 2020

Status: Active, not recruiting

Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: August 5, 2020

Status: Active, not recruiting

Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors


Conditions: Carcinoma, Merkel Cell, Carcinoma, Carcinoma, Squamous Cell, Mesothelioma, Neuroendocrine Tumors, Nasopharyngeal Carcinoma, Lung Neoplasms, Carcinoma, Neuroendocrine

Last Updated: July 28, 2020

Status: Active, not recruiting

Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies


Conditions: Neoplasms, Peritoneal Neoplasms

Last Updated: June 30, 2020

Status: Active, not recruiting

Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma


Conditions: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Mesothelioma

Last Updated: June 30, 2020

Status: Active, not recruiting

Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: June 10, 2020

Status: Active, not recruiting

A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549


Conditions: Carcinoma, Non-Small-Cell Lung, Melanoma, Mesothelioma, Triple Negative Breast Neoplasms, Neoplasms, Squamous Cell, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Adrenocortical Carcinoma

Last Updated: May 27, 2020

Status: Active, not recruiting

Intracavitary Cisplatin-Fibrin Localized Chemotherapy After P/D or EPP for Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: May 26, 2020

Status: Active, not recruiting

Psychosocial Needs and Exploration of Online Support for Patients With Mesothelioma


Conditions: Mesothelioma

Last Updated: May 8, 2020

Status: Active, not recruiting

Pembrolizumab in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: April 27, 2020

Status: Active, not recruiting

CheckpOiNt Blockade For Inhibition of Relapsed Mesothelioma


Conditions: Mesothelioma

Last Updated: April 20, 2020

Status: Active, not recruiting

Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion


Conditions: Mesothelioma, Pleural Effusion, Malignant, Pleural Effusion

Last Updated: March 12, 2020

Status: Active, not recruiting

Nivolumab Monotherapy or Nivolumab Plus Ipilimumab, for Unresectable Malignant Pleural Mesothelioma (MPM) Patients


Conditions: Mesothelioma

Last Updated: February 11, 2020

Status: Active, not recruiting

Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: February 6, 2020

Status: Active, not recruiting

A Study of LY3023414 in Participants With Advanced Cancer


Conditions: Neoplasms, Mesothelioma

Last Updated: February 3, 2020

Status: Active, not recruiting

Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma


Conditions: Vaccinia, Mesothelioma, Pleural Effusion, Malignant, Pleural Effusion

Last Updated: January 17, 2020

Status: Active, not recruiting

Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma, Lung Neoplasms

Last Updated: January 2, 2020

Status: Active, not recruiting

Diadem to Investigate the Activity and Safety of Durvalumab


Conditions: Mesothelioma

Last Updated: October 3, 2019

Status: Active, not recruiting

Vinorelbine in Mesothelioma


Conditions: Mesothelioma

Last Updated: April 29, 2019

Status: Active, not recruiting

Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent


Conditions: Mesothelioma

Last Updated: February 11, 2019

Status: Active, not recruiting

Linda is the editor in chief at Mesothelioma.com.
Written by

Linda Molinari Editor in Chief

Linda Molinari has more than 15 years of experience as a writer and advocate for mesothelioma patients and a ban on asbestos.


Full Bio Editorial Guidelines
Annette is a patient support coordinator.
Reviewed By

Annette Charlevois Patient Support Coordinator

Annette Charlevois is a senior paralegal at the law firm of Early, Lucarelli, Sweeney & Meisenkothen, helping patients find medical and legal resources.


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