The 3 Most Common Treatments for Malignant Mesothelioma Cancer

The 3 Most Common Mesothelioma Treatments

Malignant mesothelioma treatment varies based on patient goals and characteristics. In many cases, doctors recommend surgery-based combination therapies. This often means surgery and some form of chemotherapy. For inoperable cases, most patients receive chemo, immunotherapy or both.

1: Chemotherapy

Chemotherapy uses tumor-killing medicines to treat cancer. It comes in 2 basic forms: systemic and local. Mesothelioma patients with inoperable tumors often receive systemic chemo. Patients with operable tumors often undergo local chemo after surgery.

Systemic chemo usually involves the drug combo of Alimta® (pemetrexed) and cisplatin. But in some cases, doctors may recommend carboplatin instead of cisplatin.

Local chemo is usually part of a combination treatment plan. You can read more about that in the related section below. Research indicates both types of chemo can extend survival for mesothelioma patients.

2: Immunotherapy

Immunotherapies empower a patient’s immune system to fight cancer. Pleural mesothelioma patients with inoperable tumors often receive Opdivo® (nivolumab) and Yervoy® (ipilimumab). Both drugs are immune checkpoint inhibitors (ICIs). They help immune cells recognize and attack cancer cells.

3: Combination (Multimodal) Treatments

Many mesothelioma patients receive more than 1 type of therapy. This approach is called multimodal treatment. It may kill more tumor cells by attacking them with different methods.

Multimodal treatments can consist of any combination of the following:

• Chemotherapy
• Immunotherapy
• Radiation
• Surgery

The recommended combination depends on tumor location and other factors. Patients with inoperable tumors may undergo radiation followed by chemo or immunotherapy. Patients with operable tumors may have surgery followed by chemo and other treatments. Surgery-based approaches include:

• Pleural mesothelioma: This type of cancer forms in the lining around the lung (the pleura). Pleural cases may be treated with surgery and heated intrathoracic chemotherapy (HITHOC).
• Peritoneal mesothelioma: This type of cancer forms in the abdominal lining (the peritoneum). Peritoneal cases may be treated with surgery and heated intraperitoneal chemotherapy (HIPEC).

There are many different ways to combine mesothelioma treatments. A mesothelioma specialist can discuss which combination may work best for each patient.

What Does This Mean for Mesothelioma Patients?

Mesothelioma patients have many treatment options. Doctors should present these choices clearly and help you understand the potential risks and benefits of each. Palliative care is a helpful option for all stages of mesothelioma. But if an oncologist only offers palliative therapies, you may want to ask about other options or get a second opinion.