Dr. Jeffrey Melson Clarke

Doctor Overview

Dr. Jeffrey Melson Clarke is a medical oncologist at Duke Cancer Center in Durham, North Carolina. He specializes in treating lung cancer, mesothelioma and tumors that have spread to the brain or spine. Besides caring for patients, he is also an associate professor of medicine at the Duke University School of Medicine.

Dr. Clarke completed his medical degree at Indiana University’s School of Medicine. His residency and fellowship training occurred at Duke. He holds several ongoing research grants for studying new lung cancer treatments. This type of research often benefits mesothelioma patients because treatments tend to work for both types of cancer.

Doctor Fast Facts

Main Specialty: Medical Oncology

Other Interests & Specialties: Lung cancer, mesothelioma and metastatic brain and spine tumors.

Certifications, Awards & Accolades: Board Certified in Medical Oncology by the American Board of Internal Medicine

Education & Experience:

• Medical Degree from Indiana University School of Medicine
• Residency in Internal Medicine at Duke University Medical Center
• Fellowship in Medical Oncology at Duke University Medical Center

Publications

Updated efficacy and safety from the phase 2 pharos study of encorafenib plus binimetinib in patients with braf v600e-mutant metastatic nsclc-a brief report. J Thorac Oncol. 2025 Oct;20(10):1538–47.

Neoadjuvant, perioperative, and adjuvant immunotherapy in early-stage surgically resectable non-small cell lung cancer: updates and future perspectives. Cancers (Basel). 2025 June 21;17(13):2077.

Differences in microenvironment of lung cancer and pleural effusions by single-cell RNA sequencing. Lung Cancer. 2024 July;193:107847.