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More than 100 mesothelioma clinical trials are currently accepting patients. Active, recruiting clinical trials accept mesothelioma cancer patients who meet certain eligibility criteria. Doctors can help interested patients understand eligibility and enrollment. Accepted patients often gain access to new and emerging therapies. 

Mesothelioma Clinical Trials Currently Accepting Patients

Mesothelioma patients may consider participating in a clinical trial. Clinical trials are medical studies involving people. There are dozens of active clinical trials recruiting mesothelioma patients who meet the eligibility requirements.

Doctors use mesothelioma clinical studies to evaluate the safety and efficacy of new treatments. If treatments perform well in clinical trials, they can go on to become approved by the U.S. Food and Drug Administration (FDA).

One example of this is the immunotherapy combination of Opdivo® and Yervoy®. Together, these drugs proved successful in clinical trials. Researchers found the combination extended patient survival. Based upon that data, the FDA approved Opdivo® and Yervoy® for the treatment of inoperable pleural mesothelioma.

Emerging Treatments in Mesothelioma Clinical Trials

  • Cancer vaccines: A type of immunotherapy that teaches the immune system to attack cancer, much like a vaccine
  • Cryotherapy: A cancer treatment that uses extremely cold material to treat mesothelioma
  • Immunotherapy: A wide variety of treatments that use the immune system to fight cancer
  • Multimodal therapy: Various combinations of two or more mesothelioma treatments
  • Photodynamic therapy: A treatment that uses light to kill cancer cells
  • Radical surgery: Aggressive surgical removal of mesothelioma tumors

These important medical studies follow a defined process. Each mesothelioma clinical trial starts with an idea, often in a research laboratory. Treatments that perform well in the lab and in animals can move on to clinical trials testing. This is the point at which researchers allow people to volunteer to help evaluate the new treatment(s).

Mesothelioma patients with limited treatment options may be able to access new treatments through clinical trials. In fact, the American Society of Clinical Oncology (ASCO) recommends clinical trial enrollment for the following pleural mesothelioma patients:

  • Patients qualifying for a second round of systemic chemotherapy (second-line) after failure of primary chemotherapy treatment
  • Patients with mesothelioma tumors or cells in nearby lymph nodes
  • Patients qualifying for pre-surgical or post-surgical radiation therapy

Like all medical treatments, clinical trial participation comes with certain risks. Patients should discuss the potential benefits and risks of enrolling in a clinical trial with their oncologists.

Additional information on clinical trial safety, process, costs and enrollment can be found on our Clinical Trials Overview page.

List of Clinical Trials Recruiting Mesothelioma Patients

Provided below is a list of mesothelioma trials that are currently accepting new patients.

Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: October 21, 2025

Status: Recruiting

A Study of SGN-MesoC2 in Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: October 14, 2025

Status: Recruiting

Lead-212 PSV359 Therapy for Patients With Solid Tumors


Conditions: Mesothelioma

Last Updated: October 14, 2025

Status: Recruiting

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection


Conditions: Mesothelioma

Last Updated: October 10, 2025

Status: Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)


Conditions: Mesothelioma

Last Updated: October 7, 2025

Status: Recruiting

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma


Conditions: Mesothelioma

Last Updated: October 7, 2025

Status: Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining


Conditions: Mesothelioma

Last Updated: October 4, 2025

Status: Recruiting

SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma


Conditions: Mesothelioma

Last Updated: October 2, 2025

Status: Recruiting

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 29, 2025

Status: Recruiting

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing


Conditions: Mesothelioma

Last Updated: September 24, 2025

Status: Recruiting

Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma


Conditions: Mesothelioma

Last Updated: September 22, 2025

Status: Recruiting

Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 18, 2025

Status: Recruiting

Rapid Autopsy and Procurement of Cancer Tissue


Conditions: Mesothelioma

Last Updated: September 12, 2025

Status: Recruiting

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy


Conditions: Mesothelioma

Last Updated: September 11, 2025

Status: Recruiting

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion


Conditions: Mesothelioma

Last Updated: September 11, 2025

Status: Recruiting

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: September 11, 2025

Status: Recruiting

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)


Conditions: Mesothelioma

Last Updated: September 8, 2025

Status: Recruiting

A Study of NX-1607 in Adults With Advanced Malignancies


Conditions: Mesothelioma

Last Updated: September 5, 2025

Status: Recruiting

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors


Conditions: Mesothelioma

Last Updated: September 1, 2025

Status: Recruiting

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers


Conditions: Mesothelioma

Last Updated: August 15, 2025

Status: Recruiting

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: August 5, 2025

Status: Recruiting

CT-95 in Advanced Cancers Associated With Mesothelin Expression


Conditions: Mesothelioma

Last Updated: July 29, 2025

Status: Recruiting

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: July 17, 2025

Status: Recruiting

SW-682 in Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: July 14, 2025

Status: Recruiting

A Study of Sacituzumab Govitecan in People With Mesothelioma


Conditions: Mesothelioma

Last Updated: July 10, 2025

Status: Recruiting

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers


Conditions: Mesothelioma

Last Updated: July 7, 2025

Status: Recruiting

A Beta-only IL-2 ImmunoTherapY Study


Conditions: Mesothelioma

Last Updated: July 3, 2025

Status: Recruiting

Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma


Conditions: Mesothelioma

Last Updated: June 18, 2025

Status: Recruiting

Integrated Cancer Repository for Cancer Research


Conditions: Mesothelioma

Last Updated: June 4, 2025

Status: Recruiting

Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery


Conditions: Mesothelioma

Last Updated: May 21, 2025

Status: Recruiting

A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma


Conditions: Mesothelioma

Last Updated: May 14, 2025

Status: Recruiting

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas


Conditions: Mesothelioma

Last Updated: May 12, 2025

Status: Recruiting

Olaparib in Patients With HRD Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: May 5, 2025

Status: Recruiting

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors


Conditions: Mesothelioma

Last Updated: May 5, 2025

Status: Recruiting

A Study of VET3-TGI in Patients With Solid Tumors


Conditions: Mesothelioma

Last Updated: April 9, 2025

Status: Recruiting

Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)


Conditions: Mesothelioma

Last Updated: January 22, 2025

Status: Recruiting

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome


Conditions: Mesothelioma

Last Updated: January 17, 2025

Status: Recruiting

Stereotactic Magnetic Resonance Guided Radiation Therapy


Conditions: Mesothelioma

Last Updated: November 4, 2024

Status: Recruiting

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI


Conditions: Mesothelioma

Last Updated: August 9, 2024

Status: Recruiting

A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: August 7, 2024

Status: Recruiting

Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU


Conditions: Mesothelioma

Last Updated: August 5, 2024

Status: Recruiting

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors


Conditions: Mesothelioma

Last Updated: June 24, 2024

Status: Recruiting

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies


Conditions: Mesothelioma

Last Updated: November 16, 2022

Status: Recruiting