Mesothelioma Clinical Trials Currently Accepting Patients
Mesothelioma patients may consider participating in a clinical trial. Clinical trials are medical studies involving people. There are dozens of active clinical trials recruiting mesothelioma patients who meet the eligibility requirements.
Doctors use mesothelioma clinical studies to evaluate the safety and efficacy of new treatments. If treatments perform well in clinical trials, they can go on to become approved by the U.S. Food and Drug Administration (FDA).
One example of this is the immunotherapy combination of Opdivo® and Yervoy®. Together, these drugs proved successful in clinical trials. Researchers found the combination extended patient survival. Based upon that data, the FDA approved Opdivo® and Yervoy® for the treatment of inoperable pleural mesothelioma.
These important medical studies follow a defined process. Each mesothelioma clinical trial starts with an idea, often in a research laboratory. Treatments that perform well in the lab and in animals can move on to clinical trials testing. This is the point at which researchers allow people to volunteer to help evaluate the new treatment(s).
Mesothelioma patients with limited treatment options may be able to access new treatments through clinical trials. In fact, the American Society of Clinical Oncology (ASCO) recommends clinical trial enrollment for the following pleural mesothelioma patients:
- Patients qualifying for a second round of systemic chemotherapy (second-line) after failure of primary chemotherapy treatment
- Patients with mesothelioma tumors or cells in nearby lymph nodes
- Patients qualifying for pre-surgical or post-surgical radiation therapy
Like all medical treatments, clinical trial participation comes with certain risks. Patients should discuss the potential benefits and risks of enrolling in a clinical trial with their oncologists.
Additional information on clinical trial safety, process, costs and enrollment can be found on our Clinical Trials Overview page.
List of Clinical Trials Recruiting Mesothelioma Patients
Provided below is a list of mesothelioma trials that are currently accepting new patients.
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
Conditions: Mesothelioma
Last Updated: October 21, 2025
Status: Recruiting
A Study of SGN-MesoC2 in Advanced Solid Tumors
Conditions: Mesothelioma
Last Updated: October 14, 2025
Status: Recruiting
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Conditions: Mesothelioma
Last Updated: October 14, 2025
Status: Recruiting
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Conditions: Mesothelioma
Last Updated: October 10, 2025
Status: Recruiting
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
Conditions: Mesothelioma
Last Updated: October 7, 2025
Status: Recruiting
Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma
Conditions: Mesothelioma
Last Updated: October 7, 2025
Status: Recruiting
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Conditions: Mesothelioma
Last Updated: October 4, 2025
Status: Recruiting
Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies
Conditions: Mesothelioma
Last Updated: October 4, 2025
Status: Recruiting
SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma
Conditions: Mesothelioma
Last Updated: October 2, 2025
Status: Recruiting
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Conditions: Mesothelioma
Last Updated: September 29, 2025
Status: Recruiting
Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy
Conditions: Mesothelioma
Last Updated: September 29, 2025
Status: Recruiting
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Conditions: Mesothelioma
Last Updated: September 24, 2025
Status: Recruiting
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Conditions: Mesothelioma
Last Updated: September 22, 2025
Status: Recruiting
Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma
Conditions: Mesothelioma
Last Updated: September 18, 2025
Status: Recruiting
Rapid Autopsy and Procurement of Cancer Tissue
Conditions: Mesothelioma
Last Updated: September 12, 2025
Status: Recruiting
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
Conditions: Mesothelioma
Last Updated: September 11, 2025
Status: Recruiting
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Conditions: Mesothelioma
Last Updated: September 11, 2025
Status: Recruiting
Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma
Conditions: Mesothelioma
Last Updated: September 11, 2025
Status: Recruiting
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Conditions: Mesothelioma
Last Updated: September 11, 2025
Status: Recruiting
Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)
Conditions: Mesothelioma
Last Updated: September 8, 2025
Status: Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
Conditions: Mesothelioma
Last Updated: September 5, 2025
Status: Recruiting
Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors
Conditions: Mesothelioma
Last Updated: September 1, 2025
Status: Recruiting
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Conditions: Mesothelioma
Last Updated: August 29, 2025
Status: Recruiting
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
Conditions: Mesothelioma
Last Updated: August 25, 2025
Status: Recruiting
Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes
Conditions: Mesothelioma
Last Updated: August 16, 2025
Status: Recruiting
A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers
Conditions: Mesothelioma
Last Updated: August 15, 2025
Status: Recruiting
Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors
Conditions: Mesothelioma
Last Updated: August 12, 2025
Status: Recruiting
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
Conditions: Mesothelioma
Last Updated: August 5, 2025
Status: Recruiting
CT-95 in Advanced Cancers Associated With Mesothelin Expression
Conditions: Mesothelioma
Last Updated: July 29, 2025
Status: Recruiting
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Conditions: Mesothelioma
Last Updated: July 17, 2025
Status: Recruiting
SW-682 in Advanced Solid Tumors
Conditions: Mesothelioma
Last Updated: July 14, 2025
Status: Recruiting
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Conditions: Mesothelioma
Last Updated: July 11, 2025
Status: Recruiting
A Study of Sacituzumab Govitecan in People With Mesothelioma
Conditions: Mesothelioma
Last Updated: July 10, 2025
Status: Recruiting
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
Conditions: Mesothelioma
Last Updated: July 7, 2025
Status: Recruiting
A Beta-only IL-2 ImmunoTherapY Study
Conditions: Mesothelioma
Last Updated: July 3, 2025
Status: Recruiting
Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Conditions: Mesothelioma
Last Updated: June 18, 2025
Status: Recruiting
Integrated Cancer Repository for Cancer Research
Conditions: Mesothelioma
Last Updated: June 4, 2025
Status: Recruiting
Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery
Conditions: Mesothelioma
Last Updated: May 21, 2025
Status: Recruiting
A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma
Conditions: Mesothelioma
Last Updated: May 14, 2025
Status: Recruiting
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
Conditions: Mesothelioma
Last Updated: May 12, 2025
Status: Recruiting
Olaparib in Patients With HRD Malignant Mesothelioma
Conditions: Mesothelioma
Last Updated: May 5, 2025
Status: Recruiting
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Conditions: Mesothelioma
Last Updated: May 5, 2025
Status: Recruiting
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
Conditions: Mesothelioma
Last Updated: April 9, 2025
Status: Recruiting
A Study of VET3-TGI in Patients With Solid Tumors
Conditions: Mesothelioma
Last Updated: April 9, 2025
Status: Recruiting
A Study to Evaluate the Safety and Efficacy of A2B694, a Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Conditions: Mesothelioma
Last Updated: March 6, 2025
Status: Recruiting
Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)
Conditions: Mesothelioma
Last Updated: January 22, 2025
Status: Recruiting
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
Conditions: Mesothelioma
Last Updated: January 17, 2025
Status: Recruiting
Stereotactic Magnetic Resonance Guided Radiation Therapy
Conditions: Mesothelioma
Last Updated: November 4, 2024
Status: Recruiting
MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
Conditions: Mesothelioma
Last Updated: August 9, 2024
Status: Recruiting
A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors
Conditions: Mesothelioma
Last Updated: August 7, 2024
Status: Recruiting
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Conditions: Mesothelioma
Last Updated: August 5, 2024
Status: Recruiting
A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors
Conditions: Mesothelioma
Last Updated: June 24, 2024
Status: Recruiting
First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies
Conditions: Mesothelioma
Last Updated: November 16, 2022
Status: Recruiting



