Clinical Trials – Recruiting

Author: Katy Moncivais, PhD

Reviewer: Annette Charlevois

Last Updated: 7/29/2025

More than 100 mesothelioma clinical trials are currently accepting patients. Active, recruiting clinical trials accept mesothelioma cancer patients who meet certain eligibility criteria. Doctors can help interested patients understand eligibility and enrollment. Accepted patients often gain access to new and emerging therapies.

Learn About Mesothelioma Clinical Trials in Our Free Guide

Mesothelioma Clinical Trials Currently Accepting Patients

Mesothelioma patients may consider participating in a clinical trial. Clinical trials are medical studies involving people. There are dozens of active clinical trials recruiting mesothelioma patients who meet the eligibility requirements.

Doctors use mesothelioma clinical studies to evaluate the safety and efficacy of new treatments. If treatments perform well in clinical trials, they can go on to become approved by the U.S. Food and Drug Administration (FDA).

One example of this is the immunotherapy combination of Opdivo® and Yervoy®. Together, these drugs proved successful in clinical trials. Researchers found the combination extended patient survival. Based upon that data, the FDA approved Opdivo® and Yervoy® for the treatment of inoperable pleural mesothelioma.

Emerging Treatments in Mesothelioma Clinical Trials

Cancer vaccines: A type of immunotherapy that teaches the immune system to attack cancer, much like a vaccine
Cryotherapy: A cancer treatment that uses extremely cold material to treat mesothelioma
Immunotherapy: A wide variety of treatments that use the immune system to fight cancer
Multimodal therapy: Various combinations of two or more mesothelioma treatments
Photodynamic therapy: A treatment that uses light to kill cancer cells
Radical surgery: Aggressive surgical removal of mesothelioma tumors

These important medical studies follow a defined process. Each mesothelioma clinical trial starts with an idea, often in a research laboratory. Treatments that perform well in the lab and in animals can move on to clinical trials testing. This is the point at which researchers allow people to volunteer to help evaluate the new treatment(s).

Mesothelioma patients with limited treatment options may be able to access new treatments through clinical trials. In fact, the American Society of Clinical Oncology (ASCO) recommends clinical trial enrollment for the following pleural mesothelioma patients:

Patients qualifying for a second round of systemic chemotherapy (second-line) after failure of primary chemotherapy treatment
Patients with mesothelioma tumors or cells in nearby lymph nodes
Patients qualifying for pre-surgical or post-surgical radiation therapy

Like all medical treatments, clinical trial participation comes with certain risks. Patients should discuss the potential benefits and risks of enrolling in a clinical trial with their oncologists.

Additional information on clinical trial safety, process, costs and enrollment can be found on our Clinical Trials Overview page.

List of Clinical Trials Recruiting Mesothelioma Patients

Provided below is a list of mesothelioma trials that are currently accepting new patients.

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Conditions: Mesothelioma
Last Updated: 2/20/2026
Status: Recruiting

Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies

Conditions: Mesothelioma
Last Updated: 2/20/2026
Status: Recruiting

Rapid Autopsy and Procurement of Cancer Tissue

Conditions: Mesothelioma
Last Updated: 2/20/2026
Status: Recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma