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Is Too Much Sitting Bad for Cancer Survivors?


Written by Tara Strand on April 9, 2025

Cancer survivors often focus on diet, medical follow-ups and mental well-being. But what about sitting? Many people don’t realize that prolonged sitting can be harmful, even after beating cancer.

A 2022 JAMA Oncology study found that cancer survivors who sit for more than 8 hours a day face a higher risk of death. On the other hand, even light activities, like standing up or taking short walks, can help lower that risk.

Keep reading to learn how small changes could make a big difference in recovery, longevity and overall health.

The Risks of a Sedentary Lifestyle

Sitting for long periods may seem harmless, especially during recovery. But research shows that sitting too much can hurt circulation and slow your metabolism. It may also cause weight gain, heart disease and other complications.

Too much sitting can also trigger inflammation, weaken the immune system and disrupt blood sugar levels. These factors may contribute to higher risks of chronic diseases, cancer recurrence and shorter lifespans.

Study: Sitting Too Much Can Increase Risks for Cancer Survivors

In a JAMA Oncology study, prolonged sitting was linked to a higher risk of death among cancer survivors. Researchers compared risks for those sitting 4 hours a day versus more than 8 hours a day. Those who sat the most had an 81% higher risk of dying from any cause.

Impact on Recovery

Cancer treatments like chemotherapy and radiation can take a toll on the body. These therapies can cause muscle weakness and fatigue. Sitting too much might worsen these effects. Research has linked prolonged sitting to:

  • Blood vessel damage
  • Increased risk of heart disease
  • Muscle loss and weakening
  • Slower blood circulation

As you might imagine, these effects have not been linked to faster recovery after cancer treatment. Not to worry, though. In the JAMA Oncology study, even light activity like standing helped reduce the negative impacts of sitting. So, even small changes can help.

Mental Health and Well-Being

Cancer survivors are more likely to experience depression, anxiety and stress. Sitting for long hours may contribute to these feelings, making it harder to stay positive and motivated. Excessive lounging may also reduce sleep quality.

Studies show that physical activity releases endorphins, the body’s natural mood boosters. Movement also improves blood flow to the brain, which could help with focus and memory.

Practical Strategies to Reduce Sitting Time

Reducing sedentary time doesn’t have to mean hitting the gym for hours. Small, simple changes can make a big difference in your health and recovery.

Breaking Up Long Sitting Periods

Even without intense exercise, breaking up long sitting periods can improve health. Standing up, stretching or walking every hour or so can improve circulation and lower health risks.

Here are some ways to sit less and move more during the day:

  • Do light household tasks like folding laundry or watering plants while standing
  • Make TV time active by marching in place during commercials
  • Set reminders to stand and stretch throughout the day
  • Walk around your house while you’re on the phone

You don’t have to do full, rigorous workouts. Standing or moving more can help reduce the harm of prolonged sitting.

The Impact of Physical Activity on Cancer Survival

A study in the Journal of the National Cancer Institute (JNCI) found that breast cancer patients who did light exercise had better survival rates than those who were inactive. While the most beneficial type of exercise is still uncertain, research from JNCI and the National Cancer Institute shows that staying active, even at a low level, can improve cancer patients’ outcomes.

Remember to start small. Listen to your body and work with your care team to make your activity choices work for you.

What Does This Mean for Mesothelioma Patients?

Sitting too much can be harmful for cancer survivors, but small changes can make a big difference. Even light activity can improve heart health, strengthen muscles and boost mental well-being. These benefits are within reach, even for mesothelioma patients in active treatment.

You don’t need to change your whole routine. Start small—stand during phone calls, take short walks or stretch between tasks. Work with your care team to build daily habits that match your needs and goals.

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Sources
  1. American Cancer Society. American Cancer Society Guideline for Diet and Physical Activity.

  2. American College of Cardiology. Sitting Too Long Can Harm Heart Health, Even for Active People.

  3. Bade BC, Thomas DD, Scott JB, Silvestri GA. Increasing physical activity and exercise in lung cancer: reviewing safety, benefits, and application. J Thorac Oncol. 2015 Jun;10(6):861–71.

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  9. Duran AT, Friel CP, Serafini MA, Ensari I, Cheung YK, Diaz KM. Breaking up prolonged sitting to improve cardiometabolic risk: dose–response analysis of a randomized crossover trial. Medicine & Science in Sports & Exercise. 2023 May;55(5):847–55.

  10. Hwang CL, Chen SH, Chou CH, Grigoriadis G, Liao TC, Fancher IS, et al. The physiological benefits of sitting less and moving more: Opportunities for future research. Prog Cardiovasc Dis. 2022;73:61–6.

  11. Meyer JD, O’Connor J, McDowell CP, Lansing JE, Brower CS, Herring MP. High sitting time is a behavioral risk factor for blunted improvement in depression across 8 weeks of the covid-19 pandemic in april-may 2020. Front Psychiatry. 2021;12:741433.

  12. Mustian KM, Sprod LK, Janelsins M, Peppone LJ, Mohile S. Exercise recommendations for cancer-related fatigue, cognitive impairment, sleep problems, depression, pain, anxiety, and physical dysfunction: a review. Oncol Hematol Rev. 2012;8(2):81–8.

  13. UT Southwestern Medical Center. Exercise boosts blood flow to the brain, study finds.

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Tara Strand, Senior Content Writer at Mesothelioma.com
Written by Tara Strand Senior Content Writer
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