Skip to Content

Completed mesothelioma clinical trials have treated all study patients and finished collecting data. Once a study is completed, researchers examine the results. They will determine how and if to move forward with the treatment or technology at hand. Completed studies have improved mesothelioma survival.

Completed Mesothelioma Clinical Trials

Clinical trials may help researchers better understand mesothelioma development and treatment. Clinical studies are considered completed once all treatments and follow-ups are done. This means researchers have collected the last data point from the last patient undergoing treatment. At this point, researchers examine the study results.

In the case of a clinical trial on mesothelioma treatment, this analysis helps answer many questions, including:

  • Was the treatment effective?
  • Did the benefits of the treatment outweigh the risks?
  • Does the treatment require further study?
  • Should the treatment be approved by the U.S. Food and Drug Administration (FDA)?

Once study coordinators have finished analyzing results, they may publish them in a medical journal. They may also share the study results in the trial’s ClinicalTrials.gov record.

For more information on clinical trials phases, processes, costs and enrollment, you can visit our Clinical Trials Overview page.

Mesothelioma Advances From Clinical Trials

Some completed clinical trials have tested treatments that substantially improved the prognosis for mesothelioma. Below are a few examples of noteworthy, completed mesothelioma clinical trials.

Immunotherapy for Inoperable Pleural Mesothelioma

Study Name: CheckMate-743

Study Purpose: To evaluate an immunotherapy combination treatment compared to standard chemotherapy (cisplatin and pemetrexed)

New Treatment: Opdivo® (nivolumab) and Yervoy® (ipilimumab)

Type of Mesothelioma: Inoperable pleural mesothelioma

Most Important Result: Improved survival. Patients treated with Opdivo® and Yervoy® had a median survival of 18.1 months. Those treated with standard chemotherapy had a median survival of 14.1 months.

FDA Approval Status: The FDA approved Opdivo® and Yervoy® for treatment of inoperable pleural mesothelioma in October 2020.

A New Treatment for Inoperable Pleural Mesothelioma

Study Name: STELLAR

Study Purpose: To determine the effect of a novel, electric field-based treatment for pleural mesothelioma

New Treatment: Novo-TTF-100L System

Type of Mesothelioma: Inoperable pleural mesothelioma

Most Important Result: Encouraging survival without increased systemic toxicity. Patients had standard chemotherapy treatment followed by Novo-TTF treatment. Median overall survival was 18.2 months, which compares favorably to other treatment options.

FDA Approval Status: The Novo-TTF-100L System gained FDA approval in 2019. It is approved for the treatment of inoperable pleural mesothelioma in combination with standard chemotherapy. Since the approval, the treatment has become more widely available to mesothelioma patients.

Improved Survival in Select Patients With Unresectable Pleural Mesothelioma

Study Name: MAPS (Mesothelioma Avastin® Plus Pemetrexed-cisplatin Study)

Study Purpose: To determine the effect of an immunotherapy drug on the survival of patients also undergoing standard chemotherapy treatment

New Treatment: Avastin® (bevacizumab)

Type of Mesothelioma: Inoperable pleural mesothelioma

Most Important Result: Improved survival. Patients treated with chemotherapy and Avastin® had a median survival of 18.8 months. Those treated with chemotherapy alone had a median survival of 16.1 months.

FDA Approval Status: The manufacturer did not submit an application for FDA approval. However, experts say Avastin® may be offered to patients who can tolerate it.

Completed Mesothelioma Clinical Trials List

Provided below is a list of completed mesothelioma trials.

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors


Conditions: Mesothelioma

Last Updated: November 21, 2025

Status: Completed

Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 4, 2025

Status: Completed

DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: July 16, 2025

Status: Completed

CART-meso in Mesothelin Expressing Cancers


Conditions: Mesothelioma

Last Updated: June 25, 2025

Status: Completed

Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: June 18, 2025

Status: Completed

Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide


Conditions: Mesothelioma

Last Updated: May 19, 2025

Status: Completed

Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma


Conditions: Mesothelioma

Last Updated: May 8, 2025

Status: Completed

CAR T Cells in Mesothelin Expressing Cancers


Conditions: Mesothelioma

Last Updated: April 25, 2025

Status: Completed

Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels


Conditions: Mesothelioma

Last Updated: February 18, 2025

Status: Completed

The Registry of Oncology Outcomes Associated with Testing and Treatment


Conditions: Mesothelioma

Last Updated: December 13, 2024

Status: Completed

Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies


Conditions: Mesothelioma

Last Updated: December 4, 2024

Status: Completed

HIPEC for Peritoneal Carcinomatosis


Conditions: Mesothelioma

Last Updated: October 22, 2024

Status: Completed

Galinpepimut-S (WT-1 Analog Peptide) Vaccine in Malignant Pleural Mesothelioma After Combined Modality Therapy


Conditions: Mesothelioma

Last Updated: October 1, 2024

Status: Completed

Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: July 29, 2024

Status: Completed

A Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: June 27, 2024

Status: Completed

A Study of Pembrolizumab and Cryoablation in People With Mesothelioma


Conditions: Mesothelioma

Last Updated: December 19, 2023

Status: Completed

A Study of Immunotherapy Drugs Nivolumab and Ipilimumab in Patients w/Resectable Malignant Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: December 12, 2023

Status: Completed

Early Palliative Care in Advanced Lung and Gastrointestinal Malignancies


Conditions: Mesothelioma

Last Updated: October 9, 2023

Status: Completed

Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: September 28, 2023

Status: Completed

A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)


Conditions: Mesothelioma

Last Updated: September 13, 2023

Status: Completed

Ph 2/3 Study in Subjects With MPM to Assess ADI-PEG 20 With Pemetrexed and Cisplatin


Conditions: Mesothelioma

Last Updated: September 9, 2023

Status: Completed

Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion


Conditions: Mesothelioma

Last Updated: August 23, 2023

Status: Completed

Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma


Conditions: Mesothelioma

Last Updated: June 29, 2023

Status: Completed

Pemetrexed Plus Gemcitabine or Carboplatin for Patients With Advanced Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: June 14, 2023

Status: Completed

Psychosocial Needs and Exploration of Online Support for Patients With Mesothelioma


Conditions: Mesothelioma

Last Updated: February 7, 2023

Status: Completed

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: November 29, 2022

Status: Completed

Dasatinib in Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: October 27, 2022

Status: Completed

Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: September 23, 2022

Status: Completed

MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 16, 2022

Status: Completed

An Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: August 24, 2022

Status: Completed

Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: July 28, 2022

Status: Completed

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors


Conditions: Mesothelioma

Last Updated: July 18, 2022

Status: Completed

Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors


Conditions: Mesothelioma

Last Updated: June 10, 2022

Status: Completed

Phase I Trial HIPEC With Nal-irinotecan


Conditions: Mesothelioma

Last Updated: May 5, 2022

Status: Completed

A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: April 13, 2022

Status: Completed

A Study of LY3023414 in Participants With Advanced Cancer


Conditions: Mesothelioma

Last Updated: April 7, 2022

Status: Completed

Intravenous Magnesium in Patients Receiving Cisplatin


Conditions: Mesothelioma

Last Updated: January 10, 2022

Status: Completed

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies


Conditions: Mesothelioma

Last Updated: November 12, 2021

Status: Completed

Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent


Conditions: Mesothelioma

Last Updated: November 10, 2021

Status: Completed

Study of CBP501 + Pemetrexed + Cisplatin on MPM (Phase I/II)


Conditions: Mesothelioma

Last Updated: June 30, 2021

Status: Completed

Olaparib in People With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: March 16, 2021

Status: Completed

Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: March 16, 2021

Status: Completed

Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 8, 2021

Status: Completed

A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies


Conditions: Mesothelioma

Last Updated: October 28, 2020

Status: Completed

Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)


Conditions: Mesothelioma

Last Updated: October 28, 2020

Status: Completed

Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: September 30, 2020

Status: Completed

Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer


Conditions: Mesothelioma

Last Updated: July 30, 2020

Status: Completed

Clinical and Histopathologic Characteristics of BAP1 Mutations


Conditions: Mesothelioma

Last Updated: June 30, 2020

Status: Completed

Anti-TGF Monoclonal Antibody (GC1008) in Relapsed Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: March 31, 2020

Status: Completed

Gene Therapy for Pleural Malignancies


Conditions: Mesothelioma

Last Updated: March 16, 2020

Status: Completed

Combination Gene Transfer and Chemotherapy


Conditions: Mesothelioma

Last Updated: March 13, 2020

Status: Completed

S0722: Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery


Conditions: Mesothelioma

Last Updated: February 19, 2020

Status: Completed

Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma


Conditions: Mesothelioma

Last Updated: October 15, 2019

Status: Completed

A Single Dose FMT Infusion as an Adjunct to Keytruda for Metastatic Mesothelioma


Conditions: Mesothelioma

Last Updated: September 19, 2019

Status: Completed

LEE011 for Patients With CDK4/6 Pathway Activated Tumors (SIGNATURE)


Conditions: Mesothelioma

Last Updated: July 16, 2019

Status: Completed

SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma


Conditions: Mesothelioma

Last Updated: June 5, 2019

Status: Completed

18F-FSPG PET/CT for Cancer Patients on Therapy


Conditions: Mesothelioma

Last Updated: December 11, 2018

Status: Completed

Erlotinib Hydrochloride in Treating Patients With Malignant Peritoneal Mesothelioma


Conditions: Mesothelioma

Last Updated: September 17, 2018

Status: Completed

Phase II Study of IMC-A12 in Patients With Mesothelioma Who Have Been Previously Treated With Chemotherapy


Conditions: Mesothelioma

Last Updated: March 13, 2018

Status: Completed

S0509 - AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery


Conditions: Mesothelioma

Last Updated: December 27, 2017

Status: Completed

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: November 27, 2017

Status: Completed

Do Your Genes Put You at a Higher Risk of Developing Mesothelioma


Conditions: Mesothelioma

Last Updated: November 3, 2017

Status: Completed

Autologous Redirected RNA Meso-CIR T Cells


Conditions: Mesothelioma

Last Updated: September 16, 2017

Status: Completed

Radical Pleurectomy/Decortication (PD) and Intensity Modulated Radiotherapy (IMRT)


Conditions: Mesothelioma

Last Updated: July 17, 2017

Status: Completed

Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)


Conditions: Mesothelioma

Last Updated: April 24, 2017

Status: Completed

Gemcitabine and Epirubicin in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: December 5, 2016

Status: Completed

Collecting Tumor Samples From Patients With Gynecological Tumors


Conditions: Mesothelioma

Last Updated: October 26, 2016

Status: Completed

A Single-Dose Pilot Study of Radiolabeled Amatuximab (MORAb-009) in Mesothelin Over Expressing Cancers


Conditions: Mesothelioma

Last Updated: September 28, 2016

Status: Completed

Capecitabine in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: July 12, 2016

Status: Completed

Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: July 11, 2016

Status: Completed

PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: June 30, 2016

Status: Completed

B-Receptor Signaling in Cardiomyopathy


Conditions: Mesothelioma

Last Updated: November 16, 2015

Status: Completed

Cisplatin, Pemetrexed, and Imatinib Mesylate in Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: November 16, 2015

Status: Completed

Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy


Conditions: Mesothelioma

Last Updated: October 19, 2015

Status: Completed

Intrapleural Gene Transfer for Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: September 21, 2015

Status: Completed

Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma


Conditions: Mesothelioma

Last Updated: July 7, 2015

Status: Completed

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: July 7, 2015

Status: Completed

Immunotoxin Therapy in Treating Patients With Advanced Cancer


Conditions: Mesothelioma

Last Updated: April 29, 2015

Status: Completed

Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors


Conditions: Mesothelioma

Last Updated: April 29, 2015

Status: Completed

Pazopanib in Treating Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: January 28, 2015

Status: Completed

Cediranib Maleate in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery


Conditions: Mesothelioma

Last Updated: July 25, 2014

Status: Completed

An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation


Conditions: Mesothelioma

Last Updated: July 23, 2014

Status: Completed

Biomarkers to Detect Mesothelioma Early in Patients Exposed to Asbestos or Vermiculite


Conditions: Mesothelioma

Last Updated: March 4, 2014

Status: Completed

Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: February 10, 2014

Status: Completed

Rapamycin With Grapefruit Juice for Advanced Malignancies


Conditions: Mesothelioma

Last Updated: January 16, 2014

Status: Completed

Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain


Conditions: Mesothelioma

Last Updated: January 14, 2014

Status: Completed

Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer


Conditions: Mesothelioma

Last Updated: July 9, 2013

Status: Completed

Alanosine in Treating Patients With Cancer


Conditions: Mesothelioma

Last Updated: June 25, 2013

Status: Completed

Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma.


Conditions: Mesothelioma

Last Updated: June 4, 2013

Status: Completed

SU5416 in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: May 31, 2013

Status: Completed

Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung


Conditions: Mesothelioma

Last Updated: January 23, 2013

Status: Completed

Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction


Conditions: Mesothelioma

Last Updated: January 15, 2013

Status: Completed

Gefitinib in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: January 15, 2013

Status: Completed

Interleukin-12 in Treating Patients With Cancer in the Abdomen


Conditions: Mesothelioma

Last Updated: July 27, 2012

Status: Completed

Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs


Conditions: Mesothelioma

Last Updated: March 14, 2012

Status: Completed

MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma


Conditions: Mesothelioma

Last Updated: March 14, 2012

Status: Completed

Bevacizumab (Avastin) and Erlotinib (Tarceva) in Previously Treated Mesothelioma


Conditions: Mesothelioma

Last Updated: December 23, 2011

Status: Completed

Phase I Study of OSI-930 and Erlotinib in Cancer Tumors


Conditions: Mesothelioma

Last Updated: September 26, 2011

Status: Completed

PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer


Conditions: Mesothelioma

Last Updated: April 23, 2011

Status: Completed

Liposomal-Cisplatin Analogue (L-NDDP) in Treating Patients With Malignant Pleural Mesothelioma


Conditions: Mesothelioma

Last Updated: March 25, 2011

Status: Completed

Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma


Conditions: Mesothelioma

Last Updated: February 25, 2011

Status: Completed