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Sai Yendamuri, M.D.

Dr. Yendamuri
Buffalo, NY

Dr. Sai Yendamuri

Thoracic Surgeon

Roswell Park Cancer Institute

Elm and Carlton Streets
Buffalo, NY 14263
(716) 845-2300

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All India Institute of Medical Sciences, New Delhi, India

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Harrison Department of Surgical Research, Philadelphia, PA
Barnes Jewish Hospital, St. Louis, MO

Dr. Sai Yendamuri is a thoracic surgeon who currently serves as chair of the department of thoracic surgery and director of the thoracic surgery laboratory at the Roswell Park Cancer Institute located in Buffalo, New York. Dr. Yendamuri’s academic posts include professor of oncology at Roswell and associate professor of surgery at Jacobs School of Medicine and Biomedical Sciences at the State University of New York, also located in Buffalo.

Educational Background

Dr. Yendamuri received his medical degree in 1997 from the All India Institute of Medical Sciences in New Delhi, India. He then went on to earn his M.P.H from the University of South Carolina in Columbia, South Carolina in 1998 before pursuing his internship at the Hospital of the University of Pennsylvania which he completed in 1999. His general surgery residency was completed in 2001 at the Medical Center of Delaware, at which time Dr. Yendamuri pursued two research fellowships—one at the Department of Surgery at the University of Pennsylvania and one at the Kimmel Cancer Center at Thomas Jefferson University—from 2001 through 2003. A second general surgery residency ensued from 2003-2005 at the New York Hospital Medical Center of Queens/Cornell University in New York, New York. In 2007, after ten years of pursuing his educational training in medicine, Dr. Yendamuri sought a position at an institution that embodied a collaborative approach among physicians and oncologists for treating lung cancer patients—Dr. Yendamuri found that multidisciplinary style of medicine at Roswell Park.

Clinical and Laboratory Research

Dr. Yendamuri’s clinical practice focuses on the treatment of thoracic malignancies through surgery with a specialty of minimally invasive thoracic surgical procedures. His areas of treatment expertise include, but are not limited to, mesothelioma, esophageal cancer, lung cancer, mediastinal tumors, and tracheal conditions. Among Dr. Yendamuri’s special interests are predicting risk using genomic markers, thoracic surgical training on a global level, molecular staging of thoracic malignancies, and lung cancer screening.

Dr. Yendamuri is currently the principal investigator of a clinical trial focusing on photodynamic therapy for patients with epithelioid malignant pleural mesothelioma.

Additional Work

A noted researcher and published author, Dr. Yendamuri is a fellow of the American College of Surgeons and a member of several professional organizations, including the American Association for Thoracic Surgery, the European Society of Thoracic Surgeons, The Society of Thoracic Surgeons, the Cardiothoracic Surgery Network, the International Society for Minimally Invasive Cardiothoracic Surgery, and the Southern Thoracic Surgical Association.

Dr. Yendamuri believes “As a doctor, you can have an immediate and lasting impact on people around you." His philosophy of practicing medicine embraces the importance of his belief that each patient should have an individualized treatment plan to meet his/her specific medical situation. Dr. Yendamuri also believes that when treating complex conditions, such as mesothelioma, that a multidisciplinary approach must be employed that involves the following three elements: chemotherapy, radiation therapy, and surgery.

A native of India, Dr. Yendamuri is continuously striving to address the fact that India has very few thoracic surgeons, especially for a country combatting high rates of tuberculosis. Dr. Yendamuri is dedicated to performing thoracic operations in his homeland, as well as training future thoracic surgeons to practice there.


Dr. Yendamuri’s published articles:
National Center for Biotechnology Information, U.S. National Library of Medicine—PubMed

Author: Linda Molinari

Editor in Chief, Mesothelioma Cancer Alliance

Linda Molinari

Reviewer: Annette Charlevois

Patient Support Coordinator

Annette Charlevois


Roswell Park Cancer Institute

The Cardiothoracic Surgery Network


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