Sioux Falls, SD
Dr. Ashraf A. Elshami
Sanford Health/Sanford Pulmonary Medicine Clinic
Temple University School of Medicine, Philadelphia, PA - 1989
University of Pennsylvania Health System, Philadelphia, PA (1989-1992)
University of Pennsylvania Medical Center, Philadelphia, PA (1992-1995)
Dr. Ashraf A. Elshami received his medical degree in 1989 from Temple University School of Medicine in Philadelphia, Pennsylvania. He went on to complete a residency in internal medicine from 1989-1992 at the University of Pennsylvania Health System also located in Philadelphia. A fellowship ensued in pulmonary disease and critical care medicine at the University of Pennsylvania Medical Center in Philadelphia which Dr. Elshami completed in 1995. He currently serves as an assistant professor of internal medicine at the University of South Dakota Sanford School of Medicine located in Sioux Falls, South Dakota. Dr. Elshami is a pulmonologist who runs his clinical practice at the Sanford Pulmonary Medicine Clinic, a division of Sanford Health, in Sioux Falls.
Dr. Elshami is board-certified in internal medicine with specialties in pulmonary disease, critical care medicine, and sleep medicine. Dr. Elshami has been a practicing pulmonologist for 25 years. He specializes in treating ailments of the lungs and respiratory system, including, but not limited to, asthma, tuberculosis, complicated chest infections, mesothelioma, and chronic obstructive pulmonary disease.
Clinical Research and Publications
Dr. Elshami has authored or coauthored several scientific, peer-reviewed articles specifically relating to mesothelioma. They are as follows:
- Molnar-Kimber KL, Sterman DH, Chang M, Kang EH, ElBash M, Lanuti M, Elshami A, Gelfand K, Wilson JM, Kaiser LR, Albelda SM. Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma. Hum Gene Ther. 1998 Sep 20;9(14):2121-33.
- Kucharczuk JC, Randazzo B, Chang MY, Amin KM, Elshami AA, Sterman DH, Rizk NP, Molnar-Kimber KL, Brown SM, MacLean AR, Litzky LA, Fraser NW, Albelda SM, Kaiser LR. Use of a "replication-restricted" herpes virus to treat experimental human malignant mesothelioma. Cancer Res. 1997 Feb 1;57(3):466-71.
- Kucharczuk JC, Raper S, Elshami AA, Amin KM, Sterman DH, Wheeldon EB, Wilson JM, Litzky LA, Kaiser LR, Albelda SM. Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates. Hum Gene Ther. 1996 Dec 1;7(18):2225-33.
- Elshami AA, Kucharczuk JC, Zhang HB, Smythe WR, Hwang HC, Litzky LA, Kaiser LR, Albelda SM. Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. 1996 Jan 20;7(2):141-8.
- Kucharczuk JC, Elshami AA, Zhang HB, Smythe WR, Hwang HC, Tomlinson JS, Amin KM, Litzky LA, Albelda SM, Kaiser LR. Pleural-based mesothelioma in immune competent rats: a model to study adenoviral gene transfer. Ann Thorac Surg. 1995 Sep;60(3):593-7; discussion 597-8.
- Elshami AA, Kucharczuk JC, Sterman DH, Smythe WR, Hwang HC, Amin KM, Litzky LA, Albelda SM, Kaiser LR. The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann Surg. 1995 Sep;222(3):298-307; 307-10.
- Smythe WR, Hwang HC, Elshami AA, Amin KM, Eck SL, Davidson BL, Wilson JM, Kaiser LR, Albelda SM. Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann Surg. 1995 Jul;222(1):78-86.
- Hwang HC, Smythe WR, Elshami AA, Kucharczuk JC, Amin KM, Williams JP, Litzky LA, Kaiser LR, Albelda SM. Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. Am J Respir Cell Mol Biol. 1995 Jul;13(1):7-16.
- Smythe WR, Hwang HC, Elshami AA, Amin KM, Albelda SM, Kaiser LR. Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy. J Thorac Cardiovasc Surg. 1995 Apr;109(4):626-30; discussion 630-1.
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