01. Doctor Overview

Doctor Overview

Dr. Ashraf A. Elshami has been a practicing pulmonologist for 25 years. He currently provides pulmonary, critical care services and sleep medicine at the Sanford USD Medical Center. Dr. Elshami can also be found at the local veteran treatment center, Sioux Falls Veterans Affairs Health Care System. In addition to serving at these two clinics, Dr. Elshami also teaches as a clinical associate professor of internal medicine at the University of South Dakota School of Medicine.

Over the course of his career, Dr. Elshami has authored and co-authored over a dozen clinical studies about various lung and respiratory conditions, including pleural mesothelioma. The studies he has participated in have focused on gene therapy and gene transfer as treatments for mesothelioma, as well as using unique viruses as a treatment.

02. Fast Facts

Doctor Fast Facts

Main Speciality: Pulmonology

Other Interests & Specialties: General pulmonary medicine, critical care medicine, interstitial lung disease and sleep medicine.

Certifications, Awards & Accolades: American Board of Internal Medicine Certification in Critical Care Medicine, American Board of Internal Medicine Certification in Pulmonary Disease, American Board of Internal Medicine Certification in Sleep Medicine, Medicare and Medicaid Electronic Health Records Incentive Program Stage 1 and Stage 2 Certification

Education & Experience:

  • Residency for Internal Medicine at University of Pennsylvania Health System
  • Fellowship for Pulmonary Disease and Critical Care Medicine at University of Pennsylvania Health System
  • Medical Degree from Temple University School of Medicine
03. Publications


Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesotheliomaHuman Gene Therapy. September 2991;9(14):2121-33.

Use of a “replication-restricted” herpes virus to treat experimental human malignant mesotheliomaCancer Research. February 1997;57(3):466-71.

Pleural-based mesothelioma in immune competent rats: a model to study adenoviral gene transferThe Annals of Thoracic Surgery. September 1995;60(3):593-7;discussion 597-598.

Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancerAmerican Journal of Respiratory Cell and Molecular Biology. July 1995;13(1):7-16. doi: 10.1165/ajrcmb.13.1.7598939

Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase geneHuman Gene Therapy. January 1996;7(2):141-8. doi: 10.1089/hum.1996.7.2-141

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