Mesothelioma Causes

Mesothelioma Causes

What Causes Mesothelioma?

Mesothelioma is a cancer that occurs in the mesothelium, a thin membrane encompassing the body’s internal organs and cavities. Mesothelioma is caused by asbestos exposure. Asbestos fibers that are inhaled through the mouth and nose may eventually become embedded in the lining of the lungs, causing harmful inflammation of the pleura and resulting in mesothelioma or asbestosis (scar tissue formation in the lungs). It has also been found that swallowing asbestos fibers could contribute to a form of the malignancy originating in the abdomen known as peritoneal mesothelioma.

Mesothelioma generally results from occupational asbestos exposure, but there are instances of environmental exposure that can also cause the disease. Often times a family member can be affected indirectly by secondhand exposure from an asbestos worker’s soiled work clothes.

Asbestos was an effective insulation material. It was used liberally in commercial and industrial products in the United States until being regulated in a joint effort between the Consumer Product Safety Commission and the Environmental Protection Agency in 1989. Occupational exposure was common among workers who encountered these products in many industries including shipbuilding, power plants, and other industrial settings.

Asbestos insulation workers appear to have the highest incidence rate of asbestos-related disease. One study reports that almost six percent of asbestos workers fall victim to mesothelioma or experience respiratory symptoms. Asbestos insulation workers are over 300 times more likely to be diagnosed with mesothelioma than those with no exposure history.

How does exposure to asbestos cause mesothelioma?

Asbestos fibers are microscopic, though they are also quite durable. For this reason, asbestos was used in a number of different industrial compounds to enhance strength and resistance to temperature extremes- two properties at which the mineral is highly adept. Asbestos exposure most often occurred among individuals who worked extensively with asbestos or asbestos-containing materials. Friable asbestos (meaning loose or airborne fibers) is easily inhaled- often without the exposed person realizing.

Mesothelioma Causes

When inhaled, asbestos lodges easily in the outer lung tissue and within the mesothelium. The mesothelium is a thin membrane of cells which produces a lubricating fluid on the surface of the organs. This lubricant allows the lung and other internal structures to expand, contract, and move freely without friction in the body cavity. There is a great deal of latency associated with mesothelioma between exposure to asbestos and the onset of symptoms.

Pleural mesothelioma is the most common variety of the disease and forms on the pleural membrane, which surrounds the lung and chest cavity. Peritoneal mesothelioma is less common and forms on the surface of the peritoneum, a thin membrane surrounding the abdominal cavity. Pericardial mesothelioma is the least common variety of the disease and forms in the cardiac cavity that envelops the heart, a mesothelial membrane known as the pericardium.

Inhaled asbestos fibers are known to be the cause of pleural mesothelioma, whereas ingested asbestos fibers are the cause of peritoneal mesothelioma. While the exact causal nature between asbestos and pericardial mesothelioma is not known, physicians and cancer researchers surmise asbestos fibers in the blood stream lodge in the outer layers of the heart’s ventricles and lodge in the pericardium. Once asbestos fibers reach the surface of the peritoneum or pericardium, the inflammation process is essentially the same as it is on the surface of the pleura.

Primary workplace exposure to the mineral was common in naval shipyards, power plants, railroad infrastructure, and other industrial jobsites. However, asbestos-related mesotheliomas have also been diagnosed in spouses or children of those exposed to asbestos. Workers often brought home dangerous asbestos fibers on their clothing, hair, or person. Those who came into contact with these fibers on the person or their clothing have developed mesothelioma as a result.

Other Contributing Factors

Mesothelioma is also causally associated with a few other factors, but many of these are attributed to the development of mesothelioma in conjunction with exposure to asbestos.

Smoking

Those who smoke are at a higher risk of mesothelioma, though smoking is more commonly associated with traditional lung carcinomas. Smoking tends to enhance risk even further in those who were also exposed to asbestos.

Radiation Exposure

While extremely rare, some mesothelioma patients attribute their diagnosis to exposure to radiation rather than exposure to asbestos. Radiation tends to transform and mutate cell growth patterns and is more commonly associated with brain and blood cancers.

Carbon Nanotubes

Research is extremely preliminary in this study, but some laboratory studies indicate a molecular similarity between asbestos mineral fibers and carbon nanotubes. Tests indicate a pronounced risk of mesothelioma in some laboratory animals implanted with carbon nanotubes.

Howard (Jack) West, M.D.

Author: Howard (Jack) West, M.D. Google+

Thoracic Oncologist, Swedish Cancer Institute in Seattle, WA

Sources:

Cancerbackup - Causes of mesothelioma
http://www.cancerbackup.org.uk/.../Causes

eMedicineHealth - Mesothelioma Causes
http://www.emedicinehealth.com/mesothelioma/page2_em.htm

Hodgson, John T. Darnton, Andrew The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure. The Annals of Occupational Hygiene. 2000. Vol. 44(8): 565-601

Lerman, Y. Radiation associated malignant pleural mesothelioma. Thorax. 1991. Vol. 46(6); 463-464

Selikoff, Irving J. Hammond, Cuyler E. Churg, Jacob. Asbestos exposure, Smoking, and Neoplasia. Journal of the American Medical Association. 1968. Vol. 204(2) 106-112

Poland, Craig A. Duffin, Rodger Kinloch, Ian. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilor study. Nature Nanotechnology. 2008. Vol. 3 423-428

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