01. Doctor Overview

Doctor Overview

Brooke Mossman, Ph.D. is a professor in the Department of Pathology & Laboratory Medicine at the University of Vermont Larner College of Medicine. There she has completed much research and published many papers relating to the science of mesothelioma cancer and asbestos exposure. She has spent much of her professional life studying asbestos-induced cancers at the university.

Dr. Mossman’s more than 30 years of research has led her to be one of the most widely cited researchers in her field, asbestos-related diseases. Due to this prolific body of work she was recognized as a distinguished professor in 2011.

02. Fast Facts

Doctor Fast Facts

Main Speciality: Pathology & Laboratory Medicine

Other Interests & Specialties: Environmental toxicology, epithelial cell differentiation, chemical and physical carcinogenesis and cell injury, pulmonary fibrosis, oxygen free radicals, molecular biology of antioxidant enzymes in the lung and cell signaling.

Certifications, Awards & Accolades: University Distinguished Professor Award, University of Vermont College of Medicine Medical Alumni Association Graduate Alumni Award, American Thoracic Society Career Achievement Recognition Award for Scientific Accomplishments, University of Vermont Medical Scholar Award for “outstanding and sustained research and scholarly contributions to both the academic discipline and the life of the University of Vermont”, Wagner Award for Historic Contributions to Mesothelioma Research

Education & Experience:

• PhD in Cell Biology from the University of Vermont
• Masters of Science in Physiology & Biophysics from the University of Vermont

03. Publications

Publications

ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. International Journal of Cancer. September 2011;129(5):1075-86. doi: 10.1002/ijc.25763

Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. Journal of Toxicology and Environmental Health, Part B: Critical Reviews. 2011;14(1-4):76-121. doi: 10.1080/10937404.2011.556047

An ERK2 Survival Pathway Mediates Resistance of Human Mesothelioma Cells to Asbestos-Induced Injury. American Journal of Respiratory Cell and Molecular Biology. November 2011;45(5):906-14. doi: 10.1165/rcmb.2010-0282OC

Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. Molecular Cancer. 2010;9:314. doi: 10.1186/1476-4598-9-314