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Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy

Brief Summary

The purpose of this study is to collect and store normal and malignant tissue from patients with gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer, an estimated 50 to 100 of each tumor type. To collect and store blood samples from patients with gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer. To create a database for the collected tissue and allow access to relevant clinical information for current and future protocols. To create tissue microarrays for each gastrointestinal cancer subtype, namely, gastric cancer, GIST, esophageal cancer, pancreas cancer, hepatocellular cancer, biliary cancer, neuroendocrine, peritoneal mesothelioma, anal cancer and colorectal cancer, to facilitate future molecular studies. To grant access to Dr Kindler, Dr. Salgia, and Dr. Catenacci to this database (as it is being acquired) of the coupled patient tissue samples (normal and malignant) and relevant clinical information for the investigation of tyrosine kinases, such as Met and Ron, receptor tyrosine kinase family members, STATs, paxillin, focal adhesion proteins, cell motility/migration proteins, tyrosine/serine/threonine kinase family members, related molecules, and downstream targets implicated in the pathogenesis of GI cancers. Examples of molecular testing include evaluation of DNA mutation, alternative splice variants, protein expression and phosphorylation, and immunohistochemistry on samples. These studies will be correlated with clinical information as stated above.

Tracking Information
First Received DateAugust 20, 2010
Last Changed DateJuly 20, 2016
Start DateJuly 2008
Anticipated Primary Completion DateOctober 2017
Primary Outcome Measures

Collect and store blood samples [Time Frame: 1 year]

create a database for the collected tissue [Time Frame: 1 year]

Secondary Outcome Measures

To create tissue microarrays for each gastrointestinal cancer subtype [Time Frame: 1 year]

Descriptive Information
PhaseN/A
Study TypeObservational
Condition
  • Gastric Cancers
Study Arms / Comparison Groups0 / 10
Recruitment Information
Recruitment StatusRecruiting
Anticipated Enrollment1000
GenderAll
AgesN/A - N/A
Accepts Healthy VolunteersNo
Contact Daniel Catenacci, MD
Email: dcatenac@medicine.bsd.uchicago.edu
Phone: 773-702-7596
Eligibility Criteria

Inclusion Criteria:

- any patient diagnosed with Gastric (stomach) Cancer, Esophageal (foodpipe) Cancer, Pancreas Cancer, Liver Cancer, Biliary (gallbladder) Cancer, Gastrointestinal Stromal Tumor, Peritoneal Mesothelioma (cancer in the lining of the abdomen), Neuroendocrine (of or relating to the cells that release a hormone into the blood in response to a neural stimulus) Tumor, Anal Cancer or Colorectal Cancer cancer that requires you to undergo a surgical or diagnostic procedure.

Administrative Information
NCTIDNCT01416714
Responsible Party,
SponsorUniversity of Chicago
Verification DateJuly 2016
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