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Molecular Predictors of Pemetrexed and Carboplatin Response in Malignant Pleural Mesothelioma (MPM) Patients

Brief Summary

The aim of the present study is to investigate the molecular predictors of pemetrexed and carboplatin response in tumor samples of a series of MPM patients extracting the DNA and genotyping for the TSER polymorphism.

Tracking Information
First Received DateMarch 23, 2009
Last Changed DateDecember 1, 2014
Start DateJanuary 2009
Actual Primary Completion DateDecember 2011
Primary Outcome Measures

Evaluate the expression and allelic variants of a panel of candidate genes involved in the resistance to drugs, the genome wide copy number changes in patients treated with drugs combination in the first line [Time Frame: one year]

Secondary Outcome Measures

Evaluate retrospectively the correlation between gene expression and polymorphisms in candidate genes and array-CGH data, immunohistochemistry data, and clinical data. [Time Frame: one year]

Descriptive Information
Study TypeObservational
Detailed Description

Malignant pleural mesothelioma (MPM) is an aggressive tumor that usually has a poor prognosis. The combination of cisplatin and pemetrexed has recently become the standard of care in the first-line treatment of MPM. For patients who are unfit to receive a cisplatin-based chemotherapy, pemetrexed alone [7] or combined with carboplatin [8] has been proposed as an alternative treatment choice. The identification of molecular predictors of effective therapy is important for maximizing therapeutic efficacy and minimizing useless treatment in cancer patients.

Recruitment Information
Recruitment StatusCompleted
Actual Enrollment121
Ages18 Years - N/A
Accepts Healthy VolunteersNo
Eligibility Criteria

Inclusion Criteria:

- MPM diagnosis

- Availability of tumor tissue to perform analysis

Exclusion Criteria :

- Other primary diagnosis

- No archival tissue available

Administrative Information
Responsible PartySponsor
SponsorIstituto Clinico Humanitas
Verification DateNovember 2014
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