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Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery

Brief Summary

RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving pemetrexed together with cisplatin and vitamin B12 may kill more tumor cells.

PURPOSE: This phase II clinical trial is studying how well giving pemetrexed together with cisplatin and vitamin B12 works in treating patients with mesothelioma of the chest that cannot be removed by surgery.

Tracking Information
First Received DateOctober 5, 2007
Last Changed DateMay 14, 2011
Start DateJune 2007
Actual Primary Completion DateMay 2011
Primary Outcome Measures

Individual dosage-adapted protocol

Secondary Outcome Measures

Relationship between pharmacokinetic and pharmacodynamic parameters


Pharmacogenetic variations (MTHFR, TS, GSTpi, ERCC1, XPD)

Descriptive Information
PhasePhase 2
Study TypeInterventional
  • Malignant Mesothelioma
  • Dietary Supplement: vitamin B12
  • Drug: cisplatin
  • Drug: pemetrexed disodium
  • Genetic: gene expression analysis
  • Other: laboratory biomarker analysis
  • Other: pharmacological study
Detailed Description



- Define an individually adapted (by dosage) protocol of pemetrexed disodium, cisplatin, and vitamin B12 in patients with unresectable pleural mesothelioma.


- Determine the relationship between pharmacokinetic and pharmacodynamic parameters (hematologic and nonhematologic).

- Analyze the inter-individual pharmacokinetic variations and the influence of the covariables on the pharmacokinetics of pemetrexed disodium.

- Analyze the impact of pharmacogenetic (MTHFR, TS, GSTpi, ERCC1, XPD) variations on the toxicity of pemetrexed disodium.

- Validate a strategy of adapting dosage.

OUTLINE: This is a multicenter study.

Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 2 hours on day 1. Treatment repeats every 3 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive vitamin B12 intramuscularly on day -7 and then every 9 weeks until chemotherapy is completed.

Blood samples are collected during the first and third courses of chemotherapy. Samples are analyzed by pharmacogenetic (MTHFR, TS, GSTpi, ERCC1, xPD), pharmacokinetic, and other pharmacological methods.

Recruitment Information
Recruitment StatusCompleted
Anticipated Enrollment60
Ages18 Years - N/A
Accepts Healthy VolunteersNo
Eligibility Criteria


Inclusion criteria:

- Histologically confirmed pleural mesothelioma

- Unresectable disease

Exclusion criteria:

- Clinically detected pleural effusion or ascites that cannot be controlled by drainage or other procedures


Inclusion criteria:

- WHO performance status 0-2

- Life expectancy > 3 months

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Creatinine clearance > 45 mL/min

- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

- Transaminases ≤ 3 times ULN (5 times ULN if liver metastases)

- Not pregnant or nursing

- Fertile patients of must use effective contraception during and for 6 months after completion of study treatment

Exclusion criteria:

- Hypersensitivity to pemetrexed disodium or any of its excipients

- Peripheral neuropathy ≥ grade 2

- Impossible to receive study therapy due to geographical, social, familial, or psychological reasons


Inclusion criteria:

- At least 28 days since prior radiotherapy (21 days for injected radiotherapy)

Exclusion criteria:

- Prior chemotherapy

- Prior yellow fever vaccine

- Inability to discontinue aspirin (> 1.3 g/day) or NSAIDs for 2 days prior to, during, and 2 days after day 1 of each course of study therapy

- Concurrent participation in another clinical study

Administrative Information
SponsorCentre Oscar Lambret
Verification DateJuly 2009
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