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Bevacizumab (Avastin) and Erlotinib (Tarceva) in Previously Treated Mesothelioma

Brief Summary

The purpose of this study is to determine whether the combination of the investigational drugs Avastin and Tarceva are effective in patients with mesothelioma who have previously been treated with chemotherapy.

Tracking Information
First Received DateAugust 29, 2005
Last Changed DateDecember 23, 2011
Start DateFebruary 2004
Actual Primary Completion DateMarch 2007
Primary Outcome Measures

To determine the response to the combination of bevacizumab and erlotinib in previously treated malignant mesothelioma [Time Frame: 3 years]

Secondary Outcome Measures

To determine the time to tumor progression [Time Frame: TBD]

to determine the duration of response [Time Frame: TBD]

to determine the median and overall survival of patients [Time Frame: TBD]

to determine the safety of the drugs administered [Time Frame: 3 years]

Descriptive Information
PhasePhase 2
Study TypeInterventional
Condition
  • Mesothelioma
Intervention
  • Drug: Erlotinib
  • Drug: Bevacizumab
Study Arms / Comparison Groups1 / 0
Detailed Description

Each cycle of study treatment lasts 21 days. The patient will take erlotinib by mouth once daily. On day 1 of every cycle, the patient will receive bevacizumab intravenously over a 30-90 minute time period.

CT scan(s), MRI(s) and/or x-ray(s) of the cancer site will be performed every 6 weeks (2 cycles) to assess the extent of the response to treatment.

Bloodwork will be performed before the first dose of erlotinib and bevacizumab at Cycle 1, Cycle 2, Cycle 3, and at the end of treatment.

At the completion of the treatment a physical exam, vital signs, blood tests, urine tests and standard radiologic testing will be performed.

The duration of study depends upon how the patients' mesothelioma responds to treatment as well as how well the patient tolerates the medication.

Recruitment Information
Recruitment StatusCompleted
Actual Enrollment37
GenderAll
Ages18 Years - N/A
Accepts Healthy VolunteersNo
Eligibility Criteria

Inclusion Criteria:

- Mesothelioma that has been previously treated with at least one chemotherapy regimen

- 18 years of age or older

- Must at least be able to walk and capable of taking care of oneself although unable to carry out work activities

- Four or more weeks since last major surgery

- Four or more weeks since last radiation therapy

- Three or more weeks since last chemotherapy

- Life expectancy of 12 weeks or more

- Blood tests that show kidneys, liver and bone marrow to be working adequately

- Able to comply with study and/or follow-up procedures

Exclusion Criteria:

- Prior exposure to Tarceva (OSI-774, erlotinib), trastuzumab, ZD1839 or C225

- Receiving anticoagulation medication other than low dose Coumadin

- Clinically significant heart disease such as uncontrolled hypertension, previous heart attack within past 12 months, uneven heartbeat, etc.

- History of central nervous system disease such as seizures not controlled with standard medical therapy, brain metastases or history of stroke

- Major surgery within 28 days of screening

- Daily treatment with aspirin or anti-inflammatory medications

- Pregnant or lactating (pertaining to women only)

- Serious or nonhealing wound, ulcer or bone fracture

- Difficulty swallowing

- A disease or disorder that interferes with ability to digest and absorb food

- History of coughing up more than 1/4 teaspoon of blood

- A medical condition that could make it unsafe for patient to participate in this study

Administrative Information
NCTIDNCT00137826
Responsible Party,
SponsorDana-Farber Cancer Institute
Verification DateDecember 2011
Mesothelioma Doctors by State
  • Trust Funds Set Aside
  • VA Benefits Available
  • Delivered within 24 hrs

Yes   No

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