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Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer

Brief Summary

RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer.

PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

Tracking Information
First Received DateSeptember 13, 2001
Last Changed DateOctober 28, 2015
Start DateMay 2000
Actual Primary Completion DateDecember 2006
Descriptive Information
PhasePhase 2
Study TypeInterventional
Condition
  • Lung Cancer
  • Malignant Mesothelioma
  • Metastatic Cancer
  • Thymoma and Thymic Carcinoma
Intervention
  • Procedure: radiofrequency ablation
Study Arms / Comparison Groups1 / 0
Detailed Description

OBJECTIVES:

- Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies.

- Determine the efficacy of this treatment, in terms of local control, in these patients.

- Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients.

OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours.

Patients are followed at 1, 3, 6, and 12 months.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Recruitment Information
Recruitment StatusCompleted
Actual Enrollment30
GenderAll
AgesN/A - N/A
Accepts Healthy VolunteersNo
Eligibility Criteria

Inclusion Criteria:

- Diagnosis of a primary or secondary intrathoracic malignancy

- Any cell type or origin

- Involving the intrapulmonary, mediastinal, or pleural/chest wall

- Inoperable primary or metastatic cancer to the lung

- Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy)

- Single or multiple lesions that are non-contiguous with vital structures or organs such as:

- Trachea

- Heart

- Aorta

- Great vessels

- Esophagus

- Less than 5 cm in largest dimension

- Accessible via percutaneous transthoracic route

- Hepatic:

- Coagulation profile normal

Administrative Information
NCTIDNCT00024076
Responsible Party,
SponsorJonsson Comprehensive Cancer Center
Verification DateJuly 2012
Mesothelioma Doctors by State
  • Trust Funds Set Aside
  • VA Benefits Available
  • Delivered within 24 hrs

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