Cisplatin (definition of)
Cisplatin is a chemotherapy drug that contains the metal platinum, hence its name (and exorbitant price tag). It is usually the first line of treatment for cancers of the testes, ovaries, lung and stomach.
Compared to most other chemotherapy drugs, the molecular structure of cisplatin is simple and entirely inorganic. The drug is administered intravenously and is initially quite effective in inhibiting tumor growth and metastasis. While there is hope for the cancer to go into remission, most patients eventually experience a recurrence of tumors that are more resistant to the drug.
Because of its toxicity, cisplatin has several serious side effects that include:
- kidney damage
- nerve damage
- nausea and vomiting
- hearing loss
- hair loss
Interestingly, cisplatin is one of the oldest drugs still available in today's pharmacopeia. It was first developed in 1845 by Dr. Michel Peyrone, after whom the drug was named. However, it not until the 1960s that the drug underwent serious testing, and it was not approved for use in cancer treatments until 1978. Cisplatin is a highly effective method of treating all types of mesothelioma cancer (like peritoneal mesothelioma and pericardial mesothelioma). Cisplatin is often recommended by oncologists. Cisplatin is marketed under the brand name Platinol.
Other common chemotherapy drugs you may consider for treating mesothelioma include: Gemcitabine and Navelbine, and Alimta®.
